grant
The Road to Destination Therapy: Developing a Durable Ambulatory Mechanical Cardiopulmonary Support for Pulmonary Hypertension
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AcuteAddressAirway infectionsAnimal ModelAnimal Models and Related StudiesAnimalsAortaArtificial Heart VentricleArtificial VentriclesAssistive TechnologyBloodBlood Reticuloendothelial SystemBlood flowBody SystemCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaringCausalityChronicClinicalCoupledDestinationsDeteriorationDevelopmentDevicesDiseaseDisease ProgressionDisorderDysfunctionEnsureEthicsEtiologyExerciseExercise PhysiologyExercise TestExercise ToleranceExtracorporeal Membrane OxygenationFaceFailureFatigueFunctional disorderGasesGoalsHeartHeart VascularHemolysisIntermediary MetabolismInterventionInvestigationKnowledgeLack of EnergyLeftLeft AtriumLeft atrial structureLifeLong-Term EffectsLung GraftingLung TransplantationManuscriptsMechanicsMedicalMembrane OxygenatorsMetabolicMetabolic ProcessesMetabolismModelingMolecular FingerprintingMolecular ProfilingOperative ProceduresOperative Surgical ProceduresOrganOrgan SystemOutcomeOvineOvisOxygenatorsPatient ObservationPatientsPerfusionPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPrognosisProtocolProtocols documentationPublishingPulmonary ArteryPulmonary GraftPulmonary HypertensionPulmonary TransplantPulmonary TransplantationPulmonary Vascular ResistancePulmonary artery structurePumpQOL improvementRecoveryResearchResistanceRespiration DisordersRespiratory DisorderRespiratory InfectionsRespiratory Tract InfectionsRestRight AtriumRight atrial structureRiskSelf-Help DevicesSheepSideSocial Support SystemSpeedStressStructureSupport SystemSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSymptomsSystemTechniquesTechnologyTimeTitrationsTransplantationVentricle-Assist DeviceWait TimeWatchful WaitingWorkassisted deviceassistive deviceatriumbiocompatibilitybiomaterial compatibilityblood pumpbreathing disordercausationcirculatory systemdeath riskdesigndesigningdevelopmentaldisease causationerythrolysisethicalexercise capacityexercise intoleranceexperimentexperimental researchexperimental studyexperimentsfacesfacialhemodynamicshigh riskimprovedimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativelung artery blood pressurelung transplantmechanicmechanicalmodel of animalmolecular profilemolecular signaturemortality riskmultidisciplinarynoveloperationoperationsovine animal modelovine modelpathophysiologypatient mobilityphysiologic stressesphysiologic stressorphysiological stressesportabilitypressurepressure in pulmonary arteriespreventpreventingpulmonarypulmonary arterial blood pressurepulmonary arterial pressurepulmonary artery pressurepulmonary artery systolic pressurequality of life improvementresistantrespiratoryrespiratory dysfunctionresponserestorationright heart failureright sided heart failureright ventricle failureright ventricular failureright ventricular heart failuresheep modelstress statestressorsurgerytransplanttreadmillventricular assist devicewearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearables
Description preview
Project Abstract
Pulmonary hypertension (PH), which causes right ventricular failure (RVF), is a life-threatening disease with
limited long-term treatment options and a 5-year survival rate of only 50% despite advances in medical therapy,
which temporarily ameliorate it. Lung transplant is the only definitive treatment; however, PH patients can…
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