grant
The physiological and molecular function of choline transport in health and metabolic disease
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252-Aminoethanol21+ years oldAddressAdultAdult HumanAffinityAminoethanolsAssayAutoregulationBindingBinding SitesBioassayBiochemicalBiochemical PathwayBiological AssayBlood PlasmaBlood SerumBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCarbonCarrier ProteinsCas nuclease technologyCat Leukemia VirusCell BodyCell Communication and SignalingCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCell membraneCellsCellular AssayCellular FunctionCellular MembraneCellular Metabolic ProcessCellular PhysiologyCellular ProcessCellular ProliferationCholesterolCholineCholine Chloride Dihydrogen PhosphateCholine GlycerophospholipidsCholine PhosphateCholine Phosphate ChlorideCholine PhosphoglyceridesClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColamineCombining SiteCompensationCytoplasmic MembraneDNA mutationDataDefectDietary ComponentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEnvironmentEthanolaminesFeLVFeline Leukemia VirusFeline Lymphoma VirusGWA studyGWASGenesGenetic ChangeGenetic DeterminismGenetic ScreeningGenetic defectGenetic mutationGenetics-MutagenesisHeadHealthHomeostasisHumanHydrophobicityImpairmentIndividualIntermediary MetabolismIntracellular Communication and SignalingLecithinLigand BindingLigandsLinkLipidsLiposomalLiposomesLiverMammaliaMammalian CellMammalsMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane Transport ProteinsMembrane TransportersMembrane-Associated ProteinsMetabolicMetabolic DiseasesMetabolic DisorderMetabolic NetworksMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoethanolamineMurineMusMutagenesisMutagenesis Molecular BiologyMutationNAFLDNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionNutrientOrganOutcomePathway interactionsPhosphatidesPhosphatidylcholinesPhosphocholinePhospholipidsPhosphorylcholinePhosphorylcholine ChloridePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlasmaPlasma MembranePlasma SerumReactive SiteReceptor ProteinReticuloendothelial System, Serum, PlasmaRoleSerumSignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessSubgroupSurface ProteinsTestingThesaurismosisTissuesTransport Protein GeneTransport ProteinsTransporter ProteinVisualizationVitaminsWorkadulthoodaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncell assaycell metabolismcellular metabaolismcholine transportercholinergiccohortconformationconformationalconformational stateconformationallyconformationsexperimentexperimental researchexperimental studyexperimentsextracellulargenetic determinantgenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglia signalingglial signalinghepatic body systemhepatic metabolismhepatic organ systemhigh-affinity choline transporterimprovedinsightliver metabolismmembrane structuremetabolism disordermouse modelmurine modelnerve signalingneural signalingneuronal signalingneurotransmissionnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseaseparalogparalogous genepathwayplasmalemmareceptorsmall moleculesocial roleuptakewhole genome association analysiswhole genome association study
Description preview
Project Summary
Nutrient homeostasis in most living cells is mediated by membrane carrier proteins, which facilitate the
translocation of small molecule metabolites across cellular membranes. Despite their clear roles in physiology
and disease, many of the small molecule carriers in mammals are poorly studied owing to their hydrophobicity.
Indeed,…
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