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The Novel Role of Cilia in Astrocyte Sevelopment

Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 13 Mar 2023Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025AblationAbscissionAffectAstrocytesAstrocytusAstrogliaBiologyBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell CycleCell Cycle ProgressionCell Division CycleCell SignalingCellsCellular MorphologyCiliaCuesDataDevelopmentDevelopmental GeneDiseaseDisorderDisparateDysfunctionEncephalonEssential GenesExcisionExtirpationFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFoundationsFunctional disorderGene TranscriptionGeneral PopulationGeneral PublicGenesGeneticGenetic TranscriptionGliaGlial CellsGoalsHandIndividualIntracellular Communication and SignalingKnowledgeKolliker's reticulumLabelLinkMammalian CellMentorshipMicro-tubuleMicrotubulesMonitorMorphologyNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurologicNeurologicalNeurological Development DisorderNeuronsNon-neuronal cellNonneuronal cellPathologyPhysiopathologyPlayPopulationPositionPositioning AttributeProliferatingRNA ExpressionRemovalResearchResearch DesignRoleSignal TransductionSignal Transduction SystemsSignalingStaining methodStainsStructureStudy TypeSurgical RemovalSynapsesSynapticSystemTimeTranscriptTranscriptionWorkastrocytic gliabiological signal transductioncell morphologycell typeciliopathydevelopmentalexperimentexperimental researchexperimental studyexperimentshandsimprovedin vivomRNA Expressionmouse modelmurine modelnerve cementneural circuitneural circuitryneurocircuitryneurodevelopmentneurodevelopmental diseaseneuron developmentneuronalneuronal developmentnovelpathophysiologyprogramsresectionsocial rolestudy designsynapsesynaptic circuitsynaptic circuitrytooltranscriptomics

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PROJECT SUMMARY
Astrocytes are the most abundant glial cell in the brain and are essential for neural circuit formation and neuron
function. Astrocytes have an indispensable role in the developing brain, yet our fundamental understanding of
how astrocytes develop trails our knowledge of neuron development. To develop, astrocytes must proliferate…

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