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The non-canonical Collagen I-DDR1 signaling regulating protein synthesis during metastasis
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 22 Dec 2023Deadline 1 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase5'-AMP-activated protein kinaseAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAffectAnoikisBindingBiologicalBladder CancerBladder NeoplasmBladder TumorsC-terminalCancer ModelCancer PatientCancerModelCell BodyCell Communication and SignalingCell DeathCell FunctionCell NucleusCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessClinicalCollagenCollagen ReceptorsDepositDepositionDown-RegulationECMEEF1AEEF1A1EEF1A1 geneElongation FactorEnergy ExpenditureEnergy MetabolismEnergy consumptionEnvironmentExtracellular MatrixExtravasationGoalsHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHumanHypoxiaHypoxicIntracellular Communication and SignalingInvadedKnowledgeLENG7LeakageLeukocyte receptor cluster (LRC) member 7Malignant Bladder NeoplasmMalignant CellMalignant Tumor of the BladderMalignant neoplasm of urinary bladderMediatingMetabolicMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungModelingModern ManMolecular InteractionNeoplasm MetastasisNuclear TranslocationNucleusNutrientO elementO2 elementOxygenOxygen DeficiencyPathway interactionsPilot ProjectsPredispositionPrimary NeoplasmPrimary TumorProcessProductionPrognosisPromoter RegionsPromotor RegionsProtein BiosynthesisProteinsPublishingReceptor SignalingRegulationReportingResearchResistanceRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSpillageSubcellular ProcessSusceptibilityT-StageTestingTranslational RegulationTranslationsTumor CellTumor Cell InvasionTumor InvasionTumor stageUrinary Bladder CancerUrinary Bladder Malignant TumorUrinary Bladder NeoplasmUrinary Bladder Tumorbiologicbiological signal transductioncancer cellcancer metastasiscancer microenvironmentcancer progressioncolonization associated with lungcolonization in the lungcolonization within the lungdeprivationdetection of nutrientdiscoidin domain receptor 1eukaryotic translation elongation factor 1 alpha-1genetic promoter elementgenetic promoter sequencehydroxymethylglutaryl-CoA-reductase kinasein vivoinsightlung colonizationlung metastasislung metastaticmetastasize to the lungmetastatic processnecrocytosisneoplasm progressionneoplastic cellneoplastic progressionnutrient deprivationnutrient sensingnutritional deprivationoverexpressoverexpressionpathwayperception of nutrientspharmacologicpilot studypromoter sequenceprotein expressionprotein synthesisprotein synthesis attenuationpulmonary colonizationpulmonary metastasispulmonary metastaticresistantresponsesocial rolesuccesstranslationtranslational attenuationtumortumor cell metastasistumor growthtumor microenvironmenttumor progression
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PROJECT SUMMARY
The activation of signaling tumor cells via the tumor micrenvironment (TME) to undergo metastasis in bladder
cancer is understudied. Clinically, increased Col I deposition correlates with bladder cancer progression (i.e.
increasing tumor stage). Our published study demonstrated that Col I induces bladder tumor cells to invade and…
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