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The neural basis for aging-dependent decline in taste function
Organization FLORIDA STATE UNIVERSITYLocation TALLAHASSEE, UNITED STATESPosted 1 Sept 2021Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPA β-42A β42A-beta 42A-beta42AD dementiaAD modelAbeta-42Abeta42Adenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAfferent NeuronsAgeAge related pathologiesAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid βAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42Amyloidβ-42Amyloidβ42AβAβ-42Aβ42BehavioralBrain regionCell BodyCell Communication and SignalingCell SignalingCellsCyclic AMPDataDegenerative Neurologic DisordersDetectionDeteriorationDrosophilaDrosophila genusDrosophila melanogasterDysfunctionEsthesiaFliesFunctional ImagingFunctional disorderG(s), alpha SubunitG(s), α SubunitG(s)alphaG(s)αGTP-Binding Protein alpha Subunits, GsGTP-Binding Protein α Subunits, GsGenesGeneticGenomic approachGs alpha Family G-ProteinGsαGustationGαsHumanImageImpairmentIntracellular Communication and SignalingInvestigationIsoformsLibrariesMT-bound tauMeasuresMediatingMemoryMemory DeficitMemory impairmentMentorsModelingModern ManMolecularMushroom BodiesNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronal DysfunctionNeuronsNeurophysiology - biologic functionPathway interactionsPhasePhenocopyPhysiologicPhysiologic ImagingPhysiologicalPhysiologyPhysiopathologyPost-Transcriptional Gene SilencingPrimary Senile Degenerative DementiaProcessProtein IsoformsRNA InterferenceRNA SeqRNA SilencingRNA interference screenRNA sequencingRNAiRNAi screenRNAi-based screenRNAseqRegulatory Ns ProteinSensationSensorySensory NeuronsSequence-Specific Posttranscriptional Gene SilencingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStimulatory Gs G-ProteinStructureStudy modelsSynapsesSynapticTasteTaste PerceptionTauopathiesTestingToxic effectToxicitiesTrainingTransgenesVariantVariationa beta peptideaberrant agingabetaabnormal agingadenosine 3'5' monophosphateage associatedage associated effectsage associated pathologiesage correlatedage dependentage dependent pathologiesage effectage induced pathologiesage linkedage relatedage related effectsage specificagedagesaging associatedaging associated pathologiesaging dependent pathologiesaging effectaging induced pathologiesaging pathologiesaging relatedaging related pathologiesalpha Subunit Stimulatory GTP-Binding Proteinalpha-Gsalzheimer modelamyloid betaamyloid-b proteinbeta amyloid fibrilbiological signal transductioncAMPcell typedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdysfunctional age related changedysfunctional agingexperimentexperimental researchexperimental studyexperimentsflyfruit flygene interactiongene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome scalegenome-widegenomewidegenomic effortgenomic strategygustatory perceptiongustatory processinggustatory responsegustatory systemhealthy aginghealthy human aginghyper-phosphorylated tauhyperphosphorylated tauimagingimpact of ageimpaired agingin vivoinfluence of ageinsightknock-downknockdownmaladaptive agingmemory dysfunctionmicrotubule bound taumicrotubule-bound taunatural agingneuralneural degenerationneural dysfunctionneural functionneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneuropathologic tauneuropathological taunormal agingnormative agingnovelpathological age related changespathological agingpathophysiologypathwayphysiological imagingprimary degenerative dementiaresponsescreeningscreeningssenile dementia of the Alzheimer typesensorsoluble amyloid precursor proteinsugarsynapsetaste processingtaste responsetaste systemtautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytooltranscriptome sequencingtranscriptomic sequencingtransgeneα-Gsτ Proteins
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PROJECT SUMMARY
Deficits in chemosensory processing are associated with healthy aging, as well as numerous neurodegenerative
disorders including Alzheimer’s Disease (AD). In many cases, chemosensory deficits are harbingers of
neurodegenerative disease, and understanding the mechanistic basis for these changes may provide insight into
fundamental…
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