grant
The Molecular and Cellular Basis of the Sleep Homeostat
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Sept 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AD dementiaAddressAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesBehaviorBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionCNS Nervous SystemCaringCell BodyCellsCentral Nervous SystemDiabetes MellitusDiseaseDisorderDrosophilaDrosophila genusEatingEncephalonEncephalon DiseasesExhibitsFood IntakeGenesGeneticGenomicsIntracranial CNS DisordersIntracranial Central Nervous System DisordersJellyfishLabelLinkLogicMental DepressionMolecularNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeuraxisNeurocyteNeurologic DisordersNeurological DisordersNeuronsObesityOrganismPartner in relationshipPrimary Senile Degenerative DementiaProteinsProteomicsResolutionRoleScienceSleepSleep DeprivationTaxesWakefulnessadipositycircadian regulationcorpulencedeficient sleepdepressiondiabetesexperiencefruit flyinadequate sleepinnovateinnovationinnovativeinsightinsufficient sleeplife spanlifespanliving systemmatememory consolidationmodel of animalneural mechanismneurological diseaseneuromechanismneuronalprimary degenerative dementiaresolutionsscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsleep controlsleep debtsleep deficiencysleep deficitsleep insufficiencysleep losssleep regulationsleep/wake regulationsocial roletooltranscriptomics
Description preview
Project Summary
Understanding why we sleep remains one of the most enduring mysteries in science. Nearly every
organism examined, even jellyfish that lack a centralized nervous system, exhibits a restorative
sleep-like state. While asleep, we cannot eat, mate, defend ourselves from predators or care for
our young. Inadequate sleep contributes to…
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