grant
The mitochondrial aspects of health disparity of hepatocellular carcinoma in Hispanic population
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Alcohol DrinkingAlcohol consumptionBig DataBigDataBioinformaticsBiologic ModelsBiological ModelsBody TissuesCancer CauseCancer EtiologyCell BodyCell modelCellsCellular modelCessation of lifeCirrhosisComplementComplement ProteinsComplexComplex I DehydrogenaseDNA mutationDataData BasesDatabasesDeathDeath RateDevelopmentDiseaseDisorderDysfunctionElectron Transport Complex IEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEtOH drinkingEtOH useEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationExhibitsFunctional disorderGenderGene ExpressionGenerationsGeneticGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGenetic predisposing factorGenotypeHBVHCC cellHCC cell lineHCVHCV infectionHaplogroupHepatitis B VirusHepatitis C virusHepatitis C virus infectionHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHigh PrevalenceHispanicHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHumanIncidenceInpatientsInvestigationLiverLiver Cells CarcinomaMediatingMetabolic DiseasesMetabolic DisorderMetabolic syndromeMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMitochondriaMitochondrial DNAModel SystemModern ManMolecularMutationNADH DH INADH Dehydrogenase Complex 1NADH Dehydrogenase INADH Q1 OxidoreductaseNADH dehydrogenase (ubiquinone)NADH-CoQ ReductaseNADH-Coenzyme Q ReductaseNADH-Ubiquinone OxidoreductaseNADH-Ubiquinone ReductaseNAFLDNeoplasm MetastasisNon-HispanicNonhispanicNot Hispanic or LatinoNuclearObesityOncogenesisOxidative StressPathologicPathway interactionsPatientsPhysiologicPhysiologicalPhysiopathologyPlayPopulationPositionPositioning AttributePreventionPrimary carcinoma of the liver cellsProceduresProteinsRegulationReportingResearchRespiratory Complex IRestRisk FactorsRoleRotenone-Sensitive Mitochondrial NADH-Ubiquinone OxidoreductaseSamplingSecondary NeoplasmSecondary TumorSouth TexasSystemTechnologyTestingThesaurismosisTimeTissue SampleTissuesUbiquinone ReductaseUnited StatesViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirus Diseasesadiposityalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakebiobankbiorepositoryburden of diseaseburden of illnesscancer metastasiscancer typecirrhoticcomplementationcomplex 1 dehydrogenasecorpulencedata basedevelopmentaldisease burdendisparity in healthdosageepidemiologic investigationepidemiology studyethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useethnic subgroupethnicity groupgenetic risk factorgenome mutationhealth disparityhepatic body systemhepatic organ systemhepatitis C infectionhepatocellular carcinoma cell linehigh riskinducible expressioninducible gene expressioninfected with HCVinfected with hepatitis Cinfected with hepatitis C virusinfection by hepatitis c virusinfection with HCVinfection with hepatitis Cinfection with hepatitis C virusinherited factorliver carcinomametabolism disordermitochondrialmitochondrial DNA alterationmitochondrial dysfunctionmortalitymortality ratemortality ratiomtDNAmtDNA alterationnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenovelpathophysiologypathwaypolymorphismprotein expressionpublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databasesocial rolesuccesstransplant centerstumor cell metastasistumorigenesistype 1 dehydrogenaseviral infectionvirus infectionvirus proteinvirus-induced disease
Description preview
Hepatocellular carcinoma (HCC) is one of the fastest-rising causes of cancer-related mortality in the United
States. The biggest risk factor for developing HCC is viral infection (HBV and HCV). Other factors include non-
alcoholic fatty liver disease (NAFLD), alcohol use, and obesity/metabolic syndromes. Genetics also plays an
important role in…
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