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The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 May 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025A β-42A β42A-beta 42A-beta42AD dementiaAD pathologyAD preventionAbeta-42Abeta42AddressAdvisory CommitteesAffectAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid depositionAmyloid βAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42Amyloidβ-42Amyloidβ42AreaAssayAutomobile DrivingAutopsyAwardAβAβ burdenAβ-42Aβ42BehaviorBioassayBiologicalBiological AssayBiological MarkersBlackBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBlood PlasmaBlood VesselsCharacteristicsClinicalClinical ResearchClinical StudyCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplementComplement ProteinsCouplesDataData AnalysesData AnalysisDelta WaveDelta Wave sleepDevelopmentDiabetes MellitusDiffusionDisparitiesDisparityDisturbance in cognitionEEGElderlyElectroencephalogramElectroencephalographyExcessive Daytime SleepinessExcessive daytime somnolenceFellowshipFoundationsFramingham Heart StudyFundingFunding MechanismsFutureGoalsGrantHealth Disparities ResearchHealth behaviorHealth disparities related researchHigh PrevalenceHispanicHistoryHomeHypertensionImageImmune PrecipitationImmunoprecipitationImpaired cognitionIndividualInterdisciplinary ResearchInterdisciplinary StudyInternshipsIntervention StrategiesInvestigatorsJackson Heart StudyLesionMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingManuscriptsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical centerMentorsMentorshipMethodsMinorityMultidisciplinary CollaborationMultidisciplinary ResearchNMR ImagingNMR TomographyNational Institutes of HealthNerve DegenerationNeuro-epidemiologyNeuroepidemiologyNeurologyNeuron DegenerationNeuropsychologiesNeuropsychologyNeurosciences ResearchNew YorkNon-HispanicNonhispanicNot Hispanic or LatinoNuclear Magnetic Resonance ImagingObstructive Sleep ApneaPETPET ScanPET imagingPETSCANPETTParentsParticipantPathologicPhysiologicPhysiologicalPhysiologyPlasmaPlasma SerumPolysomnographyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPostdocPostdoctoral FellowPrimary Senile Degenerative DementiaProceduresPsychiatryPublic HealthPublishingRaceRacesRad.-PETRecording of previous eventsResearchResearch AssociateResearch PersonnelResearch ProposalsResearch ResourcesResearch TrainingResearchersResourcesReticuloendothelial System, Serum, PlasmaRiskRisk AssessmentRoleShapesSleepSleep DisordersSleep MonitoringSleep disturbancesSlow-Wave SleepSomnographySyndrome, Sleep Apnea, ObstructiveTask ForcesTestingTrainingUnderserved PopulationUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkZeugmatographya beta peptidea-beta burdenaberrant sleepabetaabeta burdenadvanced ageadvisory teamage associatedage correlatedage dependentage linkedage relatedage specificaged brainagesaging brainalzheimer riskamyloid betaamyloid burdenamyloid-b proteinbeta amyloid burdenbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcardiovascular riskcardiovascular risk factorcareer developmentcerebrovascular contributions to Alzheimer's diseasecerebrovascular dysfunction in Alzheimer's diseaseclassroom environmentclinical practiceclinical trainingco-morbidco-morbiditycognitive changecognitive dysfunctioncognitive functioncognitive losscohortcollege atmospherecollegial atmospherecollegiate atmospherecomorbiditycomplementationdata interpretationdesigndesigningdevelopmentaldiabetesdiagnostic abilitydiagnostic capabilitydiagnostic powerdiagnostic utilitydiagnostic valuedifferences due to racedifferences in racediffers by racediffers in racediffuseddiffusesdiffusingdiffusionsdisease disparitydisrupted sleepdisturbed sleepdrivingeducation atmosphereeducational atmosphereeducational environmentexperiencegeriatrichealth disparities sciencehealth related behaviorhigh blood pressurehigh riskhistorieshomeshyperpiesiahyperpiesishypertensive diseasehypertensive disorderidentification of biomarkersidentification of new biomarkersimagingimpaired sleepimprovedin vivoindexinginnovateinnovationinnovativeintellectual atmosphereinternirregular sleeplate in lifelate lifelearning atmospherelearning environmentmarker identificationmedical collegemedical schoolsmicrotubule bound taumicrotubule-bound tauminimal riskmolecular biomarkermolecular markermulti-modalitymultimodalitynecropsyneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofilament protein Lneurofilament protein lightneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropsychologicnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetolder adultolder adulthoodparentparent grantpopulation healthpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-docpost-doctoralpost-doctoral traineepostmortempre-clinicalpreclinicalpreventpreventingprimary degenerative dementiaprofessorprogramsprospectivequality of sleeprace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial originracially differentresearch associatesschool atmosphereschool climateschool of medicinescreeningscreeningssenile dementia of the Alzheimer typesenior citizensleep amountsleep diseasessleep disruptionsleep durationsleep dysfunctionsleep dysregulationsleep episodesleep illnesssleep intervalsleep lengthsleep measurementsleep periodsleep polysomnographysleep problemsleep qualitysleep quantitysleep timesleep/wake disruptionsleep/wake disturbancesocial rolesoluble amyloid precursor proteinsubstantia albatautau Proteinstau factortime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtraining atmosphereunder served groupunder served individualunder served peopleunder served populationunderserved groupunderserved individualunderserved peopleunethicaluniversity atmosphereuptakevascularvascular burden on Alzheimer's diseasevascular contribution to Alzheimer's Diseasevascular contributions to ADvascular contributions to Alzheimer'svascular contributor to Alzheimer's diseasevascular dysfunction in ADvascular dysfunction in Alzheimer's diseasevascular risk factorwhite matterβ-amyloid burdenβamyloid burdenτ Proteins
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PROJECT SUMMARY/ABSTRACT:
This K23 resubmission is for Dr. Bubu, an Assistant Professor at NYU School of Medicine (NYUSoM), in the
Departments of Psychiatry and Population Health, who is fully committed to becoming an independently funded investigator studying how age-related and age-dependent sleep changes, and vascular risk, impact cognitive…
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