grant
The Mechanism of Sigma 1 Receptor Mediated Neuroprotection in Glaucoma
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAgonistAnterior Quadrigeminal BodyAstrocytesAstrocytusAstrogliaAxonAxonal TransportAxoplasmic TransportBiotinylationBlindnessCell BodyCell CommunicationCell DeathCell InteractionCell IsolationCell ProtectionCell SegregationCell SeparationCell Separation TechnologyCell SurvivalCell ViabilityCell secretionCell-to-Cell InteractionCellsCellular SecretionChaperoneCo-cultureCocultivationCocultureCoculture TechniquesCommon Rat StrainsCranial Nerve IICranial Nerve II DiseasesCranial Nerve II DisorderCytoprotectionDiseaseDisorderDrugsER stressExposure toEyeEyeballGenerationsGlaucomaGliaGlial CellsGlobal ChangeGoalsGrantHarvestHealthIn VitroIntermediary MetabolismInvestigationKO miceKnock-out MiceKnockout MiceKolliker's reticulumLaboratoriesLigandsMediatingMedicationMetabolic ProcessesMetabolismMiceMice MammalsMicrobeadsMicrospheresMitochondriaModelingMolecularMolecular ChaperonesMurineMusNerve CellsNerve UnitNeural CellNeural-Optical LesionNeuritesNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellNull MouseOcular HypertensionOptic DiskOptic NerveOptic Nerve DiseasesOptic Nerve HeadOptic NeuropathyOptic PapillaOptic TectumOxidative StressPathway interactionsPentazocinePharmaceutical PreparationsPredispositionProtein SecretionProteinsProteomicsRatRats MammalsRattusReceptor ActivationReceptor InhibitionRegulationReportingRetinaRetinal Ganglion CellsRoleSecond Cranial NerveSecond Cranial Nerve DiseasesSightSilicone OilsStressSuperior ColliculusSusceptibilitySystemTestingVisionVisual CortexVisual Systemadulthoodastrocytic gliacell sortingcytoprotectivedrug/agentendoplasmic reticulum stressexperienceexperimentexperimental researchexperimental studyexperimentsextracellulargenetic approachgenetic strategyglaucomatousglobal gene expressionglobal transcription profileimprovedin vivoinflammatory environmentinflammatory milieumitochondrialmouse modelmurine modelnecrocytosisnerve cementneuronalneuroprotectionneuroprotectivenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetocular hypertensiveoptic nerve disorderpathwaypreventpreventingprotection pathwayprotective effectprotective pathwayprotein protein interactionresponseretinal ganglionsecond cranial nerve disordersigma-1 receptorsocial rolesuperior colliculus Corpora quadrigeminatherapeutic targettranscriptometranslational impacttranslatomevision lossvisual corticalvisual functionvisual lossvisual tectum
Description preview
The long-term goal of our laboratory is to develop successful neuroprotective treatments for glaucoma.
Glaucoma is a blinding disease for which neuroprotective treatments are desperately needed. In the visual
system, retinal ganglion cells (RGCs) conduct impulses to the visual cortex via RGC axons which form the optic
nerve (ON). Loss of RGCs and…
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