grant
The macrophage/tuft cell SUCNR1 axis in neonatal intestinal inflammation
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 1 Mar 2020Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAdultAdult HumanAffectAgeAgonistAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBacterial AntigensBindingBlood VesselsBreast MilkBreastmilkCausalityCell BodyCell Communication and SignalingCell CountCell NumberCell ProtectionCell SignalingCellsCessation of lifeClinicalCo-cultureCocultivationCocultureCoculture TechniquesCytoprotectionDataDeathDeath RateDevelopmentDiffusionDiseaseDisorderDistalDoctor of PhilosophyEpitheliumEtiologyGI microbiomeGI microbiotaGastrointestinal DiseasesGastrointestinal microbiotaGene TranscriptionGenetic TranscriptionGoalsHumanHuman MilkHuman Mother's MilkHypoxiaHypoxicIL-13IL13IleitisImageImmune infiltratesImmune responseImmunityImmunomodulationInfantInfiltrationInflammationInflammation MediatorsInflammatoryInflammatory ResponseInjuryInnate ImmunityInterleukin-13InterventionIntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingLifeMOF syndromeMacrophageMammary Gland MilkMediatingMiceMice MammalsModelingModern ManMolecular InteractionMolecular TargetMother's MilkMotilityMucosaMucosal InflammationMucosal TissueMucositisMucous MembraneMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusMyelogenousMyeloidMφNative ImmunityNatural ImmunityNecrosisNecroticNecrotizing EnterocolitisNeonatalNon-Specific ImmunityNonspecific ImmunityOklahomaOperative ProceduresOperative Surgical ProceduresOxygen DeficiencyPathogenesisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPerinatalPeripartumPermeabilityPh.D.PhDPhenotypePorosityPremature InfantProductionRNA ExpressionReceptor ProteinRegulationResearch Project SummariesResectedResolutionRisk FactorsRoleRunawaySensorySignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSourceSuccinatesSupportive TherapySupportive careSurgicalSurgical InterventionsSurgical ProcedureTestingTherapeuticTranscriptionTranslatingVLBWVery Low Birth Weight Infantadulthoodagesantagonismantagonistbiological signal transductionbowelbowel inflammationcausationcell typecytoprotectivedevelopmentaldiffuseddiffusesdiffusingdiffusionsdigestive tract microbiomedisease causationdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiomeenteric microbiotafeedingfetalgastrointestinal disordergastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost responseileumimagingimmune cell infiltrateimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedin vitro Modelinfants born prematureinfants born prematurelyinflamed bowelinflamed gutinflamed intestineinflammatory mediatorinjuriesintestinal barrierintestinal biomeintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloramaternal milkmembermicrobialmicrobial imbalancemodel of animalmortality ratemortality ratiomouse modelmultiorgan failuremultiple organ system failuremurine modelneglectneonatal periodnoveloffspringpatient oriented outcomespre-clinicalpreclinicalprematurepremature babypremature infant humanprematuritypreterm babypreterm infantpreterm infant humanprophylacticreceptorresolutionsresponseskip lesionsmall bowelsmall moleculesocial rolesurgerysystemic inflammationsystemic inflammatory responsetherapeutically effectivetranscriptomicsuptakevascularvery low birth weight
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RESEARCH PROJECT SUMMARY
RPL: Kathryn Burge, PhD
Project Title: The macrophage/tuft cell SUCNR1 axis in neonatal intestinal inflammation
Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease of the neonatal period with an unclear,
and likely multifactorial, pathogenesis. NEC most often affects preterm, very low birthweight…
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