grant
The JNK2-NLRP3 nexus in atrial fibrillation and its anti-AF therapeutic potentials
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025(TNF)-αAddressAgingAlcohol Chemical ClassAlcohol DrinkingAlcohol IntoxicationAlcohol abuseAlcohol consumptionAlcoholic IntoxicationAlcoholsAnimal ModelAnimal Models and Related StudiesAnti-Cytokine TherapyApoptosisApoptosis PathwayArrhythmiaAssayAtrialAtrial FibrillationAttentionAuricular FibrillationBeta Proprotein Interleukin 1BioassayBiochemistryBiological AssayBiological ChemistryBody TissuesC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CaM KIICaM PK IICaM kinase IICaMKIICachectinCardiacCardiac ArrhythmiaCardiac AtriumCardiac Electrophysiologic TechniquesCardiac Electrophysiological DiagnosticsCardiovascular DiseasesCausalityCell BodyCell Communication and SignalingCell SignalingCellsClinicalClinical DataClinical TreatmentClinical TrialsComplexDataDevelopmentDiagnosisDisciplineDisparateDomestic RabbitDrugsDrunkennessDysfunctionEconomic BurdenEducationEducational aspectsEffectivenessElectrophysiologyElectrophysiology (science)EngineeringEtOH abuseEtOH drinkingEtOH intoxicationEtOH useEtiologyEvaluationFDA approvedFeedbackFoundationsFunctional disorderFutureGene TransferGeneticGoalsHeartHeart ArrhythmiasHeart AtriumHolidaysHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1RIL1R1IL1R1 geneIL1RAIL1βImmune PrecipitationImmunoblottingImmunoprecipitationInflammasomeInflammationInflammatoryInterleukin 1betaInterleukin-1 betaInterleukin-1βInternetInterventionIntracellular Communication and SignalingJN KinaseJN kinase kinaseJNKJNK Mitogen-Activated Protein KinasesJNK kinaseJNK-55JNK-activating protein kinaseJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK2JNK2 KinaseJNK2 Stress-Activated Protein KinaseJNK21B1/2JNK2AJNK2AlphaJNK2BJNK2BetaJNKKJun amino-terminal kinase kinaseKinasesKnock-outKnockoutKnowledgeLightLinkMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMAPK9MAPK9 Mitogen-Activated Protein KinaseMAPK9 geneMacrophage-Derived TNFMapsMeasurementMediatingMedicationMiceMice MammalsMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Modern ManModificationMolecularMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusMuscle CellsMyocytesNeurophysiology / ElectrophysiologyNodalOpticsOrganOrgan DonorOrganellesOryctolagus cuniculusOutcomePRKM8PRKM9PaintPathogenesisPathogenicityPathologicPathway interactionsPatientsPersonsPharmaceutical PreparationsPhosphorylationPhosphotransferase GenePhosphotransferasesPhotoradiationPhysiopathologyPlayPreinterleukin 1 BetaProgrammed Cell DeathProliferatingProtein PhosphorylationProteomicsPublic HealthRabbitsRabbits MammalsReportingRiskRisk FactorsRoleRyR2SAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSocietiesSpecific qualifier valueSpecifiedStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaSyndromeTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTherapeuticTherapeutic InterventionTissuesTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaWWWWestern BlottingWestern Immunoblottingadult youthagedaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationalcohol co-abusealcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol problemalcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeatriumbinge alcohol consumptionbinge drinkingbiological adaptation to stressbiological signal transductionc-jun Kinase-2c-jun N-Terminal Kinasecalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcardiac electrophysiologycardiovascular disordercausationclinical interventionclinical therapyconfocal imagingcytokinedesigndesigningdevelopmentaldisease causationdrug discoverydrug/agentelectrophysiologicalepisodic drinkingethanol abuseethanol consumptionethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol intoxicationethanol product useethanol useexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolhazardous alcohol useheart electrophysiologyhigh riskin vivoinnovateinnovationinnovativeinsightintervention therapyjun-NH2-Terminal Kinasemodel of animalmortalitymouse modelmultidisciplinarymurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder adultolder adulthoodopticalp54aSAPKpatch clamppathophysiologypathwaypharmacologicpopulation agingpreventpreventingproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol useprotein blottingreaction; crisissocial rolestress kinasestress responsestress-activated protein kinase 1stress; reactionstressorsuperresolution imagingtherapeutic evaluationtherapeutic targettherapeutic testingtranslational opportunitiestranslational potentialtrial regimentrial treatmentwebworld wide webyoung adultyoung adult ageyoung adulthood
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Description preview
Excessive binge alcohol intake is a well-recognized risk factor for atrial fibrillation (AF), the most common arrhythmia
with a high morbidity and mortality, yet current therapies have suboptimal effectiveness. [While aging is an
unavoidable AF risk factor, alcohol as a secondary stressor exacerbates AF risk in the aging population.] Clinical
data…
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