grant
The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) Trial
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 18 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AccelerationAddressAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessAgeAmerican Physical Therapy AssociationAreaBehavioralBiologicalBiomechanicsCardiac ChronotropismCharacteristicsCitiesClinicalCommunitiesControl GroupsCoupledDataDevelopmentDiseaseDisease ProgressionDisorderDrugsDyskinesia SyndromesEffectivenessEnrollmentExerciseGait speedGenesGeneticGenomeGenotypeHealth CareHeart RateImmediate MemoryIndividualInterventionLaboratoriesLatino PopulationLatino groupLatino individualLatino peopleLatinosLocationLower ExtremityLower LimbMeasuresMedicationMembrum inferiusMembrum superiusModelingMotorMovement Disorder SyndromesMovement DisordersNational Institutes of HealthNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersOhioOperative ProceduresOperative Surgical ProceduresOutcomeParalysis AgitansParkinsonParkinson DiseaseParticipantPatientsPerformancePersonsPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePoliciesPoliticsPopulationPosturePrescribed exercisePrimary ParkinsonismProcessPropertyProtocolProtocols documentationRandomized, Controlled TrialsRecommendationRiskRisk-associated variantRoleShort-Term MemorySiteSocietiesSodium ChlorideSpinal ColumnSpineSurgicalSurgical InterventionsSurgical ProcedureSymptomsTablet ComputerTestingTimeTrail Making TestTranslationsUnited States National Institutes of HealthUpper ExtremityUpper LimbVertebral columnagesbackbonebiologicbiomechanicalcommunity settingcostdemographicsdevelopmentaldisease controldisease durationdisease lengthdisorder controldrug/agenteffective interventionenrollexecutive controlexecutive functionexercise prescriptionexercise programfitness programiPadillness lengthimprovedinsightmotor controlneurological diseasenovelpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmaceuticalphysical therapistphysiotherapistpolygenetic risk scorespolygenic risk scoreprimary outcomeprocessing speedprognosis modelprognostic modelprogramsrandomized control trialrecruitrisk allelerisk generisk genotyperisk locirisk locusrisk variantsaltsexsocial rolesurgerytablet devicetranslationworking memory
Description preview
PROJECT SUMMARY/ABSTRACT
Despite advances in pharmaceutical and surgical approaches to the treatment of Parkinson’s disease (PD), an
effective disease modifying treatment remains elusive. A growing body of evidence supports the notion that
high intensity aerobic exercise, when delivered in a highly supervised, well-controlled laboratory setting,…
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