grant
The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium
Organization IHC HEALTH SERVICES, INC.Location Murray, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AGE receptorARDSAccountingAcuteAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdult ARDSAdult RDSAdult Respiratory Distress SyndromeBiologicalBiological MarkersBiologyCOVID associated ARDSCOVID associated acute respiratory distress syndromeCOVID induced ARDSCOVID induced acute respiratory distress syndromeCOVID related ARDSCOVID related acute respiratory distress syndromeCOVID-19 associated ARDSCOVID-19 associated acute respiratory distress syndromeCOVID-19 induced ARDSCOVID-19 induced acute respiratory distress syndromeCOVID-19 related ARDSCOVID-19 related acute respiratory distress syndromeCOVID-19/ARDSCOVID-19/acute respiratory distress syndromeCOVID/ARDSCOVID/acute respiratory distress syndromeCOVID19 associated ARDSCOVID19 associated acute respiratory distress syndromeCOVID19 induced ARDSCOVID19 induced acute respiratory distress syndromeCOVID19 related ARDSCOVID19 related acute respiratory distress syndromeCOVID19/ARDSCOVID19/acute respiratory distress syndromeCell Communication and SignalingCell SignalingClinicalClinical DataClinical TrialsCritical IllnessCritically IllDa Nang LungDataData AnalysesData AnalysisData CollectionDiseaseDisorderDrug TherapyEnrollmentFutureGoalsHeterogeneityHyaluronanImmune Cell ActivationImmunomodulationInflammationInflammatoryIntensive Care UnitsInternationalIntracellular Communication and SignalingInvestigationLeadMachine LearningMeasuresMechanical ventilationMethodologyMethodsMolecularNoiseOutcomeOutputPathologicPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPb elementPharmacological TreatmentPharmacotherapyPhenotypePlayPneumoniaPopulationProcessProgenitor CellsRAGE receptorReceptor ActivationRecordsRecoveryRoleSARS-CoV-2 associated ARDSSARS-CoV-2 associated acute respiratory distress syndromeSARS-CoV-2 induced ARDSSARS-CoV-2 induced acute respiratory distress syndromeSARS-CoV-2 related ARDSSARS-CoV-2 related acute respiratory distress syndromeSARS-CoV-2/ARDSSARS-CoV-2/acute respiratory distress syndromeSepsisSepsis and ARDSShock LungSignal TransductionSignal Transduction SystemsSignalingSiteStatistical MethodsStiff lungSubgroupSupportive TherapySupportive careSyndromeTLR proteinTarget PopulationsTechniquesTherapeuticTherapeutic TrialsToll-Like Receptor Family GeneToll-like receptorsValidationVariantVariationWorkacute respiratory distress syndrome caused by sepsisadvanced glycosylation end product receptoramphoterin receptorbio-markersbiologicbiologic markerbiological signal transductionbiomarkerclinical applicabilityclinical applicationclinical carecohortcommon treatmentcomputer scientistcoronavirus disease 2019 associated ARDScoronavirus disease 2019 associated acute respiratory distress syndromecoronavirus disease 2019 induced ARDScoronavirus disease 2019 induced acute respiratory distress syndromecoronavirus disease 2019 related ARDScoronavirus disease 2019 related acute respiratory distress syndromecoronavirus disease 2019/ARDScoronavirus disease 2019/acute respiratory distress syndromecoronavirus disease associated ARDScoronavirus disease associated acute respiratory distress syndromecoronavirus disease induced ARDScoronavirus disease induced acute respiratory distress syndromecoronavirus disease related ARDScoronavirus disease related acute respiratory distress syndromecoronavirus disease/ARDScoronavirus disease/acute respiratory distress syndromecytokinedata interpretationdesigndesigningdisease phenotypedrug interventiondrug treatmentenrollexperienceheavy metal Pbheavy metal leadimmune activationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedimproved outcomeindividuals with sepsisinjury and repairinjury to tissueinnovateinnovationinnovativemachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmachine statistical learningmechanical respiratory assistmechanically ventilatedmolecular biomarkermolecular markermortalitynovelparticipant enrollmentpathwaypatient enrollmentpatient oriented outcomespatient responsepatient specific responsepatients with sepsispeople with sepsispharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprospectivereceptor for AGEreceptor for advanced glycation end productreceptor for advanced glycation endproductsreceptor of AGErepurposingresponse to therapyresponse to treatmentresponsive patientsepsis ARDSsepsis acute respiratory distress syndromesepsis and acute respiratory distress syndromesepsis associated acute respiratory distress syndromesepsis groupssepsis induced ARDSsepsis induced acute respiratory distress syndromesepsis patientssepsis populationsepsis related acute respiratory distress syndromesepsis subjectsseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectsevere acute respiratory syndrome coronavirus 2 associated ARDSsevere acute respiratory syndrome coronavirus 2 associated acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 induced ARDSsevere acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 related ARDSsevere acute respiratory syndrome coronavirus 2 related acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2/ARDSsevere acute respiratory syndrome coronavirus 2/acute respiratory distress syndromesocial culturesocial determinantssocial rolesocio-culturalsocioculturalsociodeterminantstatistic methodsstatistical and machine learningstem cellssubjects with sepsistargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetissue injurytissue repairtreatment responsetreatment responsivenessvalidationswet lung
Description preview
Project Summary
This proposal presents the Intermountain West-Atlantic Center (InterACT), which brings together four robust
investigative sites to participate in the APS Phenotypes Consortium. InterACT proposes to use robust
statistical and machine learning methods to phenotype patients with Acute Respiratory Distress Syndrome
(ARDS), pneumonia,…
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