grant
The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making
Organization VIRGINIA POLYTECHNIC INST AND ST UNIVLocation BLACKSBURG, UNITED STATESPosted 15 Mar 2026Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026Adult-Onset Diabetes MellitusAffectAnimal ModelAnimal Models and Related StudiesAppetiteAreaAssociation LearningAssociative LearningAttenuatedAutomobile DrivingBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiomedical ResearchBrainBrain Nervous SystemBrain regionCaloriesCarbohydratesCell Communication and SignalingCell SignalingChoice BehaviorCirculationClinicalClinical TrialsComplementComplement ProteinsComputer ModelsComputerized ModelsConditioning TherapyCorpus StriatumCorpus striatum structureCuesDEXADXADataData AnalysesData AnalysisDecision MakingDesire for foodDoctor of PhilosophyDopamineDrug TherapyDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryEatingEating BehaviorEncephalonEnvironmentFacultyFoodFood IntakeFood PreferencesFoundationsFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsHeterogeneityHumanHumulin RHydroxytyramineHypothalamic structureHypothalamusImpairmentIndividualInsulinInsulin ResistanceIntermediary MetabolismIntervention StudiesIntracellular Communication and SignalingInvestigatorsK01 AwardK01 MechanismK01 ProgramKetosis-Resistant Diabetes MellitusKnowledgeLearningMapsMaturity-Onset Diabetes MellitusMeasuresMentored Research Scientist Development AwardMentored Training AwardMentorsMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMissionModern ManNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNerve Impulse TransmissionNerve TransmissionNeurobiologyNeuronal TransmissionNeurosciencesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientOGTTObesityOral Glucose Tolerance TestOutcomePatternPavlovian conditioningPeripheralPersonsPh.D.PhDPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacotherapyPhenotypePhysiologic PsychologyPhysiological PsychologyPhysiologyPilot ProjectsProcessPsychophysiologicalPsychophysiologyPublic HealthRegular InsulinReproducibilityResearchResearch DesignResearch InstituteResearch PersonnelResearch Scientist Development AwardResearchersRewardsRoleSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStriate BodyStriatumStudy TypeT2 DMT2DT2DMTechnical ExpertiseTherapeuticThesaurismosisTimeTrainingTranslatingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited StatesUpdateWorkadiposityadult onset diabetesassociative conditioningattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbehavior interventionbehavioral interventionbiological signal transductionbrain morphologyburden of diseaseburden of illnesscaloriecareerclassical conditioningco-morbidco-morbiditycognitive neurosciencecomorbiditycomplementationcomputational modelingcomputational modelscomputational neurosciencecomputer based modelscomputerized modelingcorpulencecustomized therapycustomized treatmentdata acquisitiondata acquisitionsdata interpretationdiet choicediet preferencedietary choicedietary preferencesdisease burdendrivingdrug interventiondrug treatmentenergy balanceexpectationfMRIfood choiceglia signalingglial signalingglycemic controlhealthy weighthypothalamicimprovedindividualized medicineindividualized patient treatmentindividualized strategiesindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeinsightinsulin resistantinsulin sensitivityinsulin toleranceintervention designintervention researchinterventional researchinterventional studyinterventions researchketosis resistant diabetesmaturity onset diabetesmembermetabolism disordermodel of animalnerve signalingneuralneural imagingneural networkneural signalingneuro-imagingneurobehavioralneurobiologicalneuroimagingneurological imagingneuronal signalingneurotransmissionnovelobesity interventionobesity therapyobesity treatmentpatient specific therapiespatient specific treatmentpersonalized strategiespharmaceuticalpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphysiopsychologypilot studypreferenceprogramspsycho-physiologicalresponsereward processingskillssocial rolestatistical analysisstriatalstudy designsymptom treatmentsymptomatic treatmenttailored medical treatmenttailored therapytailored treatmenttechnical skillstenure processtenure tracktherapy designtreat symptomtreatment designtype 2 DMtype II DMtype two diabetesunique treatment
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PROJECT SUMMARY
This proposal is for a K01 Mentored Research Scientist Development Award for Mary Elizabeth Baugh, PhD,
RD. Dr. Baugh’s long-term goal is to become an independent investigator studying the synergistic role of
metabolic and neural signals on energy balance and eating behaviors and translating these insights into novel,…
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