grant
The Impact of Soluble ST2 on Lung Injury Onset and Resolution
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ARDSAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAdvisory CommitteesAirway failureAlgorithmsAllergic DiseaseAllergic asthmaAlveolarAnimal ModelAnimal Models and Related StudiesAnimalsAsthmaAutoregulationAwardB Cell Differentiation Factor IB cell growth factorB cell growth factor 2B-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCGF-IIBCGF2BCSF 1BSF-1BSF1BindingBinetrakinBiological MarkersBiometricsBiometryBiostatisticsBlood PlasmaBody TissuesBronchial AsthmaCaringCausalityCell BodyCell Communication and SignalingCell SignalingCellsClinicalClinical TrialsDa Nang LungDataDependenceDevelopmentDiseaseDisorderDrug TargetingEnvironmentEo-CSFEosinophil Differentiation FactorEpithelial CellsEpitheliumEtiologyExtrinsic asthmaFellowshipFibrosisGeneral HospitalsGeneticGoalsGrippeHomeostasisHumanIL-13IL-4IL-5IL13IL4 ProteinIgA enhancing factorImmuneImmune MarkersImmune responseImmune signalingImmunesImmunityImmunologic MarkersImmunologyInflammationInflammation MediatorsInflammatoryInfluenzaInterleukin 5 PrecursorInterleukin-13Interleukin-4Interleukin-4 PrecursorInterleukin-5Intracellular Communication and SignalingIsoformsKO miceKnock-out MiceKnockout MiceLeadLearningLungLung InflammationLung Respiratory SystemLung Tissue FibrosisLung damageLymphocyte Stimulatory Factor 1MCGF-2MaintenanceMassachusettsMast Cell Growth Factor-2MeasuresMediatingMembraneMentorsMentorshipMiceMice MammalsModelingModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMurineMusNull MouseObservation researchObservation studyObservational StudyObservational researchOutcomePathogenesisPathologicPathway interactionsPatientsPb elementPhysiciansPhysiological HomeostasisPlasmaPlasma SerumPlayPneumonitisPostdocPostdoctoral FellowProbabilistic ModelsProbability ModelsProductionProgressive DiseaseProtein IsoformsProteomicsPublishingPulmonary EdemaPulmonary FibrosisPulmonary InflammationRajidaeReceptor ProteinRecoveryRegulationRegulatory PathwayResearchResearch AssociateResolutionRespiratory FailureReticuloendothelial System, Serum, PlasmaRisk FactorsRoleSamplingScientistSepsisSeveritiesShock LungSignal TransductionSignal Transduction SystemsSignalingSkatesSourceStatistical ModelsStiff lungT cell replacing factorT-Cell Growth Factor 2T-Cell Replacing FactorTask ForcesTestingTherapeuticTherapeutic InterventionTimeTissuesTrainingTraining ActivityTransgenic AnimalsTranslational ResearchTranslational ScienceValidationVentilatorWorkadvisory teamanimal dataatopic asthmabench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationcausationcohortcytokinedesigndesigningdevelopmentaldisease causationexperienceextrinsic allergic asthmafibrosis in the lungheavy metal Pbheavy metal leadhost responsehuman datahuman diseasehuman modelidentification of biomarkersidentification of new biomarkersimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunoresponseimprovedindexinginflammatory mediatorinhibitorinjury recoveryinsightintervention therapyknock-out animalknockout animallung edemalung fibrosislung injurylung repairlung tissue repairmarker identificationmedical collegemedical schoolsmembrane structuremodel of animalmodel of humanmortalitymouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoutcome predictionparticipant enrollmentpathwaypatient enrollmentpharmacologicpost-docpost-doctoralpost-doctoral traineepreventpreventingprogramsprospectivepulmonary damagepulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryreceptorrecovery after injuryrecovery following injuryrecovery post injuryrepairrepairedresearch associatesresolutionsschool of medicineskillssocial rolestatistical linear mixed modelsstatistical linear modelstooltraining moduletranslation researchtranslational investigationvalidationswet lung
Description preview
Project Summary
Candidate: Jehan Alladina, MD is a physician-scientist at Massachusetts General Hospital (MGH) and
Harvard Medical School (HMS). Her post-doctoral research interrogated type 2 (T2) immune pathways in
allergic asthma. Building on that work, this proposal investigates the role of T2 immunity in acute respiratory
distress syndrome…
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