grant
The Impact of p53 Variants on Liver Disease
Organization MEDICAL UNIVERSITY OF SOUTH CAROLINALocation CHARLESTON, UNITED STATESPosted 3 Apr 2020Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Active OxygenAffectAfricanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAmino AcidsAntioncogene Protein p53AntioxidantsApoptosisApoptosis PathwayBehavioralBiologicalBody TissuesCOBRECRISPRCRISPR/Cas systemCancer BurdenCancer CauseCancer EtiologyCancer cell lineCancersCarbon TetrachlorideCell BodyCell Cycle ArrestCell DeathCell LineCell ProtectionCellLineCellsCellular ExpansionCellular GrowthCellular Tumor Antigen P53Cellular injuryCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCessation of lifeCirrhosisClustered Regularly Interspaced Short Palindromic RepeatsCodeCoding SystemCysteineCytoprotectionDNA DamageDNA InjuryDNA mutationDataDeathDefectDevelopmentDigestive DiseasesDigestive System DiseasesDigestive System DisordersDiseaseDisorderDisparitiesDisparityDoctor of PhilosophyDrugsEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationFe elementFe overloadFibrosisFoundationsFundingGEM modelGEMM modelGI tract disorderGene TargetingGene variantGeneralized GrowthGenesGeneticGenetic ChangeGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic PolymorphismGenetic defectGenetic mutationGenetically Engineered MouseGerm-Line MutationGlutathioneGoalsGrowthHCC cellHCC cell lineHalf-CystineHep G2HepG2HepG2 cell lineHepatic CancerHepatic DisorderHepatocarcinomaHepatocarcinoma modelHepatocellular CarcinomaHepatocellular cancerHepatomaHereditary MutationHumanImmuneImmune mediated therapyImmunesImmunocompetentImmunologically Directed TherapyImmunotherapyImpairmentIn VitroIndividualInjury to LiverIronIron OverloadKnock-inL-CysteineLaboratoriesLipidsLiverLiver Cells CarcinomaLiver FibrosisLiver diseasesMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMediatingMedicationMentorsMiceMice MammalsModelingModern ManMolecular Tumor SuppressionMurineMusMutationNational Cancer BurdenOncogene ActivationOncoprotein p53Oxygen RadicalsP53Ph.D.PhDPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePhosphoprotein P53Phosphoprotein pp53PlayPopulationPredispositionPrimary carcinoma of the liver cellsPro-OxidantsPrognosisProgrammed Cell DeathProtein TP53ProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqReactive Oxygen SpeciesRecombinant DNA TechnologyReportingResearchResearch GrantsResearch Project GrantsResearch ProjectsRiskRisk FactorsRoleSingle Base PolymorphismSingle Nucleotide PolymorphismSomatic MutationStrains Cell LinesSurvival RateSusceptibilityTP53TP53 geneTRP53TestingTetrachloromethaneTherapeuticTissue GrowthTissuesToxinTumor CellTumor Protein p53Tumor Protein p53 GeneTumor SuppressionTumor Suppressor ProteinsUnited StatesVariantVariationXenograft Modelallelic variantaminoacidanti-cancerbiologiccancer riskcareercell damagecell growthcell injurycellular damagecirrhoticcultured cell linecytoprotectivedamage to cellsdefined contributiondevelopmentaldigestive disorderdigestive tract diseasedisease riskdisorder riskdrug use screeningdrug/agentefficacious therapyefficacious treatmentenvironmental stressesenvironmental stressorethnic subgroupethnicity groupfibrotic livergamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinegastrointestinal tract diseasegastrointestinal tract disordergenetic variantgenetically engineeredgenetically engineered mouse modelgenetically engineered murine modelgenome mutationgenomic variantgerm-line defectgermline varianthepatic body systemhepatic damagehepatic diseasehepatic fibrosishepatic injuryhepatic organ systemhepatocellular carcinoma cancer modelhepatocellular carcinoma cell linehepatocellular carcinoma modelhepatopathyhigh riskimmune competentimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedin vivoindividualized therapeuticinjury to cellsknockinliver cancerliver cancer modelliver carcinomaliver damageliver disorderliver injuryliver malignancymalignancymalignant liver tumormouse modelmurine modelnecrocytosisneoplasm/cancerneoplastic cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyp53 Antigenp53 Genesp53 Tumor Suppressorpersonalized therapeuticpharmaceuticalpolymorphismprogramsprotein p53responsesenescencesenescentsingle nucleotide variantsocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssomatic variantstandard of caretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttetrachloro-methanetranscriptome sequencingtranscriptomic sequencingtumortumor suppressorxenograft transplant modelxenotransplant model
Description preview
Research Project 3 – Abstract
The TP53 tumor suppressor is arguably one of the most important genes in cancer, given that it is inactivated by
somatic mutations in about 50% of human tumors. p53 serves to protect cells in response to numerous biological
and environmental stresses, such as DNA damage, reactive oxygen species (ROS), and oncogene…
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