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The impact of IL-4 and IL-4-producing cells on protective immunity to tuberculosis
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 8 Dec 2023Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationAddressAffectAfrica South of the SaharaAllergic DiseaseAntibodiesAreaAsthmaAttenuatedAutomobile DrivingB Cell Differentiation Factor IB cell growth factorB cell growth factor 2B-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCG immunizationBCG vaccinationBCG-vaccinatedBCGFBCGF-1BCGF-IIBCGF2BCSF 1BSF-1BSF1Bacille Calmette-Guerin vaccinatedBacille Calmette-Guerin vaccinationBacillus Calmette-Guerin vaccinationBacillus Calmette-Guérin vaccinationBinetrakinBlood EosinophilBreedingBronchial AsthmaC57BL/6 MouseCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeChildChild YouthChildren (0-21)ChronicClinicalClinical DataCommunitiesCountryDeathDiseaseDisorderDrug resistance in MtbDrug resistance in Mycobacterium TuberculosisDrug resistant M TuberculosisDrug resistant MtbDrug resistant Mycobacteria TuberculosisEnvironmentEo-CSFEosinophil Differentiation FactorEosinophilic GranulocyteEosinophilic LeukocyteEpidemiological dataEpidemiology dataGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic propensityGenotypeGenus MycobacteriumGrowthHelminthsHost resistanceHumanIL-13IL-4IL-5IL13IL4 ProteinIgA enhancing factorImmuneImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologistImpairmentInbred StrainInbred Strains MiceInbreedingInfantInfectionInherited PredispositionInherited SusceptibilityInterleukin 5 PrecursorInterleukin-13Interleukin-4Interleukin-4 PrecursorInterleukin-5Intracellular Communication and SignalingKnowledgeLaboratory miceLinkLungLung DiseasesLung Respiratory SystemLung TBLung TuberculosisLymphocyte Stimulatory Factor 1M . tuberculosis resistanceM bovisM tbM tuberculosisM tuberculosis infectionM. bovisM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMCGF-2MTB infectionMTB vaccineMacrophage ActivationMapsMarrow EosinophilMarrow Mast CellMast Cell Growth Factor-2MeasuresMediatingMiceMice MammalsModelingModern ManMouse StrainsMtb drug resistanceMtb resistanceMurineMusMycobacterial InfectionMycobacteriumMycobacterium InfectionsMycobacterium bovisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycobacterium tuberculosis resistanceMycobacterium tuberculosis var. bovisParasitesParasitic WormsPathogenesisPersonsPhenotypePopulationPredispositionPredisposition geneProductionPulmonary DiseasesPulmonary DisorderPulmonary TBPulmonary TuberculosisRecombinantsRegulationRegulatory T-LymphocyteResearchResearch ProposalsRoleSchemeSchool-Age PopulationSignal TransductionSignal Transduction SystemsSignalingSub-Saharan AfricaSubsaharan AfricaSusceptibilitySusceptibility GeneT cell replacing factorT-Cell Growth Factor 2T-Cell Replacing FactorTB immunityTB infectionTB vaccineTestingTh-2 CellTh2 CellsTissue BasophilsTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisTranslatingTregTuberculosisTuberculosis VaccinesType 2 Helper CellVaccination acquired immunityVaccination induced immunityVaccine for TBVaccine for TuberculosisVaccinesanalyze gene expressionanti-TB vaccineattenuateattenuatesbiological signal transductioncell typeclinical relevanceclinically relevantcytokinedisease of the lungdisorder of the lungdisseminated TBdisseminated tuberculosisdrivingdrug resistance M Tuberculosisdrug resistance Mycobacteria Tuberculosisdrug resistant M.tbeosinophilepidemiologic datagene expression analysisgene expression assaygenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedglobal healthhelminth infectionhelminthic infectionhost responseimmune system responseimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmunoresponsein vivoinfected with helminthinfection due to Mycobacterium tuberculosisinsightkidslung disordermast cellmastocytemouse modelmtbmurine modelontogenypredisposing genepreventpreventingpulmonaryregulatory T-cellsresistance in M . tuberculosisresistance in Mycobacterium tuberculosisresistant M . tuberculosisresistant Mtbresistant Mycobacterium tuberculosisresponsescRNA sequencingscRNA-seqschool agesegregationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesusceptibility allelesusceptibility locussusceptibility varianttherapeutic evaluationtherapeutic testingtooltranscriptional profilingtuberculosis immunitytuberculosis infectiontuberculous spondyloarthropathyvaccine acquired immunityvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine associated immunityvaccine candidates against tuberculosisvaccine-induced immunityvaccine-induced protectionyoungster
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Description preview
Abstract. Why 5-10% of people develop tuberculosis (TB) after Mycobacterium tuberculosis (Mtb) infection is
largely unknown. Th1 immunity is the dominant mechanism of control. In contrast, how type 2 immunity affects
immunity to TB is a clinically important knowledge gap. Th2 immune responses are elicited by helminths
parasites, and half of the…
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