grant
The impact of biobehavioral factors and aspirin on ovarian cancer biology
Organization PONCE SCHOOL OF MEDICINELocation PONCE, UNITED STATESPosted 25 Sept 2012Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Acetylsalicylic AcidAspirinAssayAttenuatedBioassayBiologicalBiological AssayCancer BiologyCancer CenterCase SeriesCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesChronic stressClinicalDataDiagnosisDistressDoseDrug TherapyELISAEndocrine Gland SecretionEnzyme-Linked Immunosorbent AssayEpithelial ovarian cancerEvaluationExpression SignatureFutureGene ExpressionGene Expression ProfileGenesHealth SciencesHormonesHospitalsHumanImmuneImmunesImmunityImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammationInflammatoryInterventionLevarterenolLevonorepinephrineMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMeasuresMental DepressionModern ManNoradrenalineNorepinephrineOutcomeOvarian TumorOvary CancerOvary NeoplasmsOvary TumorPathway interactionsPatient Self-ReportPatientsPharmacological TreatmentPharmacotherapyProcessProspective cohortProstaglandinsProstanoidsPuerto RicoRNA SeqRNA sequencingRNAseqResearch ResourcesResourcesRoleSamplingScienceSelf-ReportSerousServicesStressSympathetic Nervous SystemTherapeutic HormoneTimeTumor TissueUniversitiesUpregulationWorkattenuateattenuatesbiobankbiobehaviorbiobehavioralbiologicbiorepositorycancer microenvironmentcancer progressioncancer riskcancer survivalcase-controlled studiesdepressiondrug interventiondrug treatmenteducation researchenzyme linked immunoassayexomeexperiencegene expression patterngene expression signatureimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinnovateinnovationinnovativemouse modelmurine modelneoplasm progressionneoplastic progressionnoveloutreachovarian cancerovarian cancer preventionovarian neoplasmpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation basedpreventpreventingpsychosocialresponserestraint stresssocial roletranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtumortumor growthtumor microenvironmenttumor progression
Description preview
Growing evidence indicates that the biological response to chronic stress and subsequent distress can promote
the progression of epithelial ovarian cancer via prolonged activation of the sympathetic nervous system and
sustained norepinephrine release. Downstream consequences of norepinephrine exposure include increased
prostaglandin-related…
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