grant
The Genetics of Personalized Functional MRI Networks
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 16 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202612-20 years old21+ years old22q1122q11 Chromosomal Microdeletion Syndrome22q11 Deletion Syndrome22q11.2 deletion syndrome22q11.2DS22q11DS9 year old9 years of ageAccelerationAdolescenceAdolescentAdolescent YouthAdultAdult HumanAgeAnatomic SitesAnatomic structuresAnatomyAreaAtlasesAutosomal dominant Opitz G/BBB syndromeAwardBehavioralBrainBrain Nervous SystemCandidate Disease GeneCandidate GeneCayler cardiofacial syndromeChildhoodChromosome 22q11.2 deletion syndromeClassificationClinicalClinical TrialsCognitionCognitive deficitsCommunitiesCopy Number PolymorphismDataData SetDetectionDevelopmentDi George syndromeDiGeorge SyndromeDiGeorge anomalyDiGeorge sequenceEncephalonFunctional ImagingFunctional MRIFunctional Magnetic Resonance ImagingFutureGWA studyGWASGenesGeneticGenetic DiversityGenetic RiskGenetic VariationGenetic studyGenomeGenomicsGoalsHereditaryHeritabilityHumanIndividualInformaticsInheritedInvestigationJointsMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental HealthMental HygieneMental disordersMental health disordersMethodologyMethodsModelingModern ManNMR ImagingNMR TomographyNeural DevelopmentNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNuclear Magnetic Resonance ImagingOutcomeParticipantPersonsPhenotypePhysiciansPhysiologic ImagingPsychiatric DiseasePsychiatric DisorderPsychological HealthPsychopathologyReportingReproducibilityResearchRiskRisk-associated variantSNP arraySNP chipSamplingScientistSedlackova syndromeShprintzen syndromeSiteStandardizationSurfaceSyndromeSystematicsTestingTimeTranslational ResearchTranslational ScienceTwin Multiple BirthTwinsVariantVariationWorkYouthYouth 10-21Zeugmatographyabnormal psychologyadolescence (12-20)adulthoodage 9age 9 yearsagesassociation cortexassociation corticalassociation corticesbehavioral healthbiobankbiorepositorybrain sizecareercase controlcase-controlledcognitive defectscognitive developmentcohortconotruncal anomaly face syndromecopy number variantcopy number variationdevelopmentaldevelopmental geneticsexecutive controlexecutive functionfMRIfamilial third and fourth pharyngeal pouch syndromefunctional genomicsfunctional outcomesgene locusgene networkgenetic architecturegenetic associationgenetic locusgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusglobal gene expressionglobal transcription profileimage processingimaging geneticsimprovedinnovateinnovationinnovativeinsightjuvenilejuvenile humanlife spanlifespanmachine based learningmental illnessnetwork dysfunctionneural controlneural regulationneurodevelopmentneurogeneticsneuromodulationneuromodulatoryneuroregulationnine year oldnine years of agenovelolder adultolder adulthoodopen dataopen scienceopen-source datapediatricpersonalized geneticspharyngeal pouch syndromephysiological imagingprecision geneticspsychiatric illnesspsychological disorderrisk allelerisk generisk genotyperisk locirisk locusrisk variantsensory cortexsexsingle nucleotide polymorphism arraysingle nucleotide polymorphism chipthird and fourth pharyngeal pouch syndromethymic and parathyroid agenesis syndrometooltranscriptometranslation researchtranslational investigationvelo-cardio-facial syndromevelocardiofacial syndromevelofacial hypoplasiawhole genome association analysiswhole genome association studyyouth age
Description preview
ABSTRACT
Variability in the spatial layout of human brain functional networks on the anatomic cortex is a novel phenotype
that can be extracted from functional magnetic resonance imaging (fMRI) with transformative potential for
combined imaging-genetics studies of human brain function. Early results show that the individual-specific
topography of…
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