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The functions of the claustrum in flexible decision making.

Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 10 Dec 2024Deadline 19 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD/HDADHDASDAction PotentialsAffectAnatomic SitesAnatomic structuresAnatomyAnimalsAreaAttention deficit hyperactivity disorderAutismAutistic DisorderBehaviorBehavioralBrainBrain Nervous SystemCell NucleusCerebral cortexClaustral structureClaustrumCognitiveCorpus StriatumCorpus striatum structureDataDecision MakingDiseaseDisorderEarly Infantile AutismEncephalonExhibitsFutureHealthImpairmentInfantile AutismKanner's SyndromeLateralLearningLesionMapsMedialMental disordersMental health disordersMiceMice MammalsModelingMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNucleusOutcomeOutputPathway interactionsPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrefrontal CortexProbabilityPropertyPsychiatric DiseasePsychiatric DisorderPsychological reinforcementReinforcementReversal LearningRewardsRoleSchizophreniaSchizophrenic DisordersSensoryStimulusStriate BodyStriatumStructureSynapsesSynapticSystemTask PerformancesTestingTransmissionautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavior influencebehavioral influencecognitive controldementia praecoxexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblehomotypical cortexisocortexmental illnessneocorticalneopalliumneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalneuropsychiatric diseaseneuropsychiatric disorderpathwaypsychiatric illnesspsychological disorderresponseschizophrenicsocial rolestriatalsynapsesynaptic circuitsynaptic circuitrytheoriestransmission process

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Description preview

PROJECT SUMMARY:
Cognitive flexibility is disrupted in many neuropsychiatric diseases, but how the brain generates flexible
behavior is not fully understood. Learning from recent actions requires neural mechanisms that maintain
information about relevant decision variables to influence future decisions. Persistent activity in cortical areas…

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The functions of the claustrum in flexible decision making. — JOHNS HOPKINS UNIVERSITY | UNITED STATES | Dec 2024 | Dev Procure