grant
The epigenetic regulation of alloimmune stem-like CD4+ T cells
Organization METHODIST HOSPITAL RESEARCH INSTITUTELocation HOUSTON, UNITED STATESPosted 3 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AlloantigenAllograftingApoptosisApoptosis PathwayAreaAutomobile DrivingCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiac TransplantationCas nuclease technologyCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCell Cycle ArrestCellsChIP SequencingChIP-seqChIPseqCharacteristicsChromatin Remodeling ComplexChromatin Remodeling FactorClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDataDepositDepositionDysfunctionEffector CellEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFoundationsFunctional disorderGene Down-RegulationGene TranscriptionGeneHomologGenesGenetic MarkersGenetic TranscriptionGoalsGraft RejectionHeart GraftingHeart TransplantationHistone H3HomologHomologous GeneHomologueImpairmentInduction of ApoptosisL-LysineLysineMapsMediatingMiceMice MammalsModelingModificationMurineMusOutcomePhysiopathologyPolycombProcessProgrammed Cell DeathRNA ExpressionRNA SeqRNA sequencingRNAseqRegulatory T-LymphocyteRepressionRoleSET DomainStem Cell likeT-Cell ProliferationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTeaTeff cellTestingTherapeuticTimeTranscriptionTranscription RepressionTransgenic OrganismsTransplant RejectionTransplantationTransplantation RejectionTregallograft rejectioncardiac allograftcardiac graftchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromatin modifierclinical relevanceclinically relevantdrivingeffector T cellepigenetic regulationepigeneticallyexhaustiongene biomarkergene expression biomarkergene markergene repressiongene signature biomarkergenetic biomarkerheart allograftheart transplanthistone H3 methyltransferasehistone methylasehistone methylationhistone methyltransferaseimprovedin vivoinhibitormutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpathophysiologypreservationpreventpreventingprogenitor capacityprogenitor cell likeprogenitor-likeregulatory T-cellsresponseself-renewself-renewalsocial rolestem cell characteristicsstem-likestemnesssuccessthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransgenictransplant
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Summary
T cells are central to transplant rejection, driving allograft destruction through differentiation into effector
cells. However, the mechanisms by which effector T cells sustain persistent alloimmune responses remain
unclear. Our recent studies have identified a subset of “stem-like” T cells within the alloreactive pool. These
stem-like T…
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