grant

The Effects of Obesity on Limiting Brain Health and Stroke Recovery

Organization MEDICAL UNIVERSITY OF SOUTH CAROLINALocation CHARLESTON, UNITED STATESPosted 7 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Academic Medical CentersActivities of Daily LivingActivities of everyday lifeAddressApoplexyAssayAwardBehaviorBioassayBiological AssayBiological MarkersBrain StemBrain Vascular AccidentBrainstemCNS Nervous SystemCNS plasticityCell Communication and SignalingCell SignalingCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalCommunicationComplexCorticospinal TractsDiffusionDysfunctionE-stimEEGEffectivenessElectric StimulationElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EquilibriumExhibitsFeedbackFoundationsFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGoalsHypesthesiaHypoesthesiaImageImpaired SensationImpairmentIndividualIndividual DifferencesIntracellular Communication and SignalingInvestigationInvestigatorsKnowledgeLearningLower ExtremityLower LimbMeasuresMediatingMediatorMedical RehabilitationMedulla SpinalisMembrum inferiusMembrum superiusMentorsMentorshipMethodsMotorMotor CortexMotor Evoked PotentialsMotor outputMuscleMuscle TissueNervous SystemNeuraxisNeurologic Body SystemNeurologic Organ SystemNeuronal PlasticityNeurophysiology / ElectrophysiologyObesityOutcomePerformancePhasePhysiopathologyPostdocPostdoctoral FellowProcessPrognosisProtocolProtocols documentationQOLQuality of lifeRecoveryReduced SensationRehabilitationRehabilitation therapyResearchResearch AssociateResearch PersonnelResearch TrainingResearchersRoleRouteSensorySensory impairmentShapesSignal TransductionSignal Transduction SystemsSignalingSomatosensory CortexSomatosensory Evoked PotentialsSpinal CordStimulusStrokeStructureSynapsesSynapticSystemTactile HypesthesiaTechniquesTimeTrainingTranscranial magnetic stimulationTranslationsUniversity Medical CentersUpper ExtremityUpper LimbWalkingWorkadiposityafter strokebalancebalance disorderbalance functionbalance impairmentbalance recoverybio-markersbiologic markerbiological signal transductionbiomarkerbrain attackbrain healthcareercareer developmentcentral nervous system plasticitycerebral vascular accidentcerebrovascular accidentconventional therapyconventional treatmentcorpulencedaily living functiondaily living functionalitydiffuseddiffusesdiffusingdiffusionsdisturbed balanceelectrophysiologicalelectrostimulationequilibration disorderequilibrium disorderexperiencefMRIfall riskfallsfunctional abilityfunctional capacityfunctional independencehigh riskimagingimprovedindependent ambulationinterestmethod developmentmulti-modalitymultimodalitymuscularneuralneural controlneural correlateneural imagingneural plasticityneural regulationneuro-imagingneuroimagingneurological imagingneuromodulationneuromodulatoryneurophysiologicalneurophysiologyneuroplasticneuroplasticityneuroregulationnovelpathophysiologypost strokepost-docpost-doctoralpost-doctoral traineepost-synaptic nervespost-synaptic neuronspoststrokepostsynaptic nervespostsynaptic neuronspre-docpre-doctoralpre-synaptic nervepre-synaptic neuronspresynaptic nervepresynaptic neuronsrehab therapyrehabilitativerehabilitative therapyresearch associatesresponseresponse to therapyresponse to treatmentsensory cortexsensory inputsensory integrationskillssocial rolesomesthetic sensory cortexspasticitystroke recoverystroke survivorstrokedstrokessynapsetherapeutic responsetherapy responsetranslationtreatment responsetreatment responsiveness
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PROJECT SUMMARY/ABSTRACT
After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to

perform activities of daily living. Post-stroke walking recovery is mediated by nervous system reorganization (e.g.,

neuroplasticity), however our understanding of these processes related to improvements…

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