grant
The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels
Organization TULANE UNIVERSITY OF LOUISIANALocation NEW ORLEANS, UNITED STATESPosted 10 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252-photon microscopyAIDSAIDS VirusAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAgingAnimalsAreaBBB disruptionBBB functionBlood - brain barrier anatomyBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBlood PlasmaBlood brain barrier dysfunctionBlood capillariesBlood flowBlood-Brain BarrierBrainBrain Nervous SystemBrain Vascular TraumaCausalityCell BodyCellsCellular injuryCerebral endotheliumCerebrovascular TraumaCerebrumChronicCirculationClinicalCoagulation Factor ICoagulation Factor OneCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplicationCultured CellsDataDephosphinDevelopmentDiseaseDisorderDisturbance in cognitionDynaminDysfunctionENOSEncephalonEndogenous Nitrate VasodilatorEndothelial CellsEndothelial Nitric Oxide SynthaseEndotheliumEndothelium-Derived Nitric OxideEtiologyEventExposure toExtravasationFactor IFactor OneFibrinogenFunctional disorderHIVHIV 1 associated neurocognitive disorderHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV therapyHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-IHIV-associated neurocognitive disorderHIV1Hemato-Encephalic BarrierHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Impaired cognitionImpairmentInfectionInfiltrationInjuryLAV-HTLV-IIILeadLeakageLinkLymphadenopathy-Associated VirusM mulattaM. mulattaMacaca mulattaMacaca rhesusMaintenanceMeasuresMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMetabolicMiceMice MammalsMitochondriaModern ManMononitrogen MonoxideMurineMusNOS3NOS3 geneNational Institutes of HealthNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurocyteNeurologic DisordersNeurologic DysfunctionsNeurological DisordersNeuronsNeuropathogenesisNitric OxideNitric Oxide Synthase 3Nitrogen MonoxideNitrogen ProtoxideNutrientOxidative StressPathogenicityPatientsPb elementPersonsPhosphorylationPhysiopathologyPlasmaPlasma SerumPlayPredispositionProductionProtein PhosphorylationProteinsPublishingRegimenRegulationReportingResearchRespirationReticuloendothelial System, Serum, PlasmaRhesus MacaqueRhesus MonkeyRoleSHIVSIVScienceSimian Immunodeficiency VirusesSiteSpillageSusceptibilityTestingTherapeuticToxinType III nitric oxide synthaseUnited States National Institutes of HealthVascular Brain InjuryVascular EndotheliumVirus-HIVabnormal brain functionantiretroviral therapyantiretroviral treatmentarterioleblood-brain barrier disruptionblood-brain barrier functionbloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier functionbrain dysfunctionbrain endothelial cellbrain endotheliumbrain healthbrain impairmentbrain microvascular endothelial cellbrain microvasculaturebrain microvesselsbrain vascular endothelial cellcapillarycardiac disease induced cognitive impairmentcausationcell damagecell injurycellular damagecerebralcerebral endothelial cellcerebral microvascular endothelial cellcerebral microvasculaturecerebral microvesselscerebral vascular endothelial cellcerebral vascular injurycerebrovascular contribution to cognitive impairment and dementiacerebrovascular injurychallenge in rhesus macaquesclinical relevanceclinically relevantcognitive dysfunctioncognitive losscortical endotheliumdamage to cellsdevelopmentaldisease causationdysfunctional brainendothelial cell derived relaxing factorendothelial dysfunctionextracellular vesiclesheavy metal Pbheavy metal leadhumanized micehumanized mouseinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinjuriesinjury to cellsinnovateinnovationinnovativeknock-downknockdownmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmitochondrialmitochondrial dysfunctionmouse modelmurine modelneural inflammationneuroinflammationneuroinflammatoryneurological diseaseneurological dysfunctionneuronalnon-human primatenonhuman primatenovelpathophysiologypreventpreventingrespiratory mechanismrhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virussocial roletherapeutically effectivetwo photon excitation microscopytwo photon microscopyuptakevascular cognitive impairment and dementiavascular contribution to impairment or dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavenulevesicle releasevesicular release
Description preview
Combined antiretroviral therapy (cART) suppresses HIV replication, but 30-60% of infected patients suffer from
severe HIV-1 associated neurocognitive disorders (HAND). However, the mechanisms underlying HAND are
unclear and this lack of information has prevented the development of effective science-driven treatments. Our
data have provided key…
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