grant
The Developmental Transition of Neural Stem Cell Niches in the Human Brain
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2033
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAdultAdult HumanBrainBrain Nervous SystemCell BodyCellsChildChild YouthChildren (0-21)Connector NeuronDataDevelopmentEGF ReceptorEGFRERBB ProteinElectron MicroscopyEmbryoEmbryonicEncephalonEntorhinal AreaEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsFore-BrainForebrainGenerationsGliaGlial CellsGoalsHER1HumanInfantIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronKnowledgeKolliker's reticulumLifeLinkMiceMice MammalsModern ManMurineMusNeocortexNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural Stem CellNeurocyteNeurogliaNeuroglial CellsNeurologic DisordersNeurological DisordersNeuronsNon-neuronal cellNonneuronal cellOrganoidsOutputProductionProgenitor CellsProliferatingProsencephalonReceptor SignalingRodentRodentiaRodents MammalsRoleSourceSpecific qualifier valueSpecifiedStreamTGF-alpha ReceptorTransforming Growth Factor alpha ReceptorUrogastrone ReceptorWorkadulthoodc-erbB-1c-erbB-1 Proteincognitive functiondevelopmentalentorhinal cortexerbB-1erbB-1 Proto-Oncogene ProteinerbBlfrontal cortexfrontal lobegenetic approachgenetic strategygliogenesishomotypical cortexin vivoisocortexkidslight microscopymigrationmultiomicsmultiple omicsneopalliumnerve cementnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenesisneurogenic progenitorsneurogenic stem cellneurological diseaseneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew approachesnovel approachesnovel strategiesnovel strategyolfactory bulbpanomicspost-natal developmentpostnatalpostnatal developmentprenatalprogenitorprogenitor and neural stem cellsprogenitor cell nicheprogenitor cell poolprogenitor cell populationprogenitor nicheprogenitor poolprogenitor populationproto-oncogene protein c-erbB-1recruitsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor cell nichestem and progenitor cell populationstem cell nichestem cell poolstem cell populationstem cellstumorunbornyoungster
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Project Summary
Our earlier work identified the neural stem cells (NSC) and intermediate progenitors that generate new
neurons and glial cells in the adult mouse brain. These NSCs are regionally specified to produce unique sets
of inhibitory interneurons that migrate along the rostral migratory stream (RMS) to the olfactory bulb. Unlike
rodents,…
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