grant
The Development of Selective Inhibitors to Oncogenic Rac1 Variants
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffinityAlternate SplicingAlternative RNA SplicingAlternative SplicingAmino AcidsAminoacetic AcidArkinAutomobile DrivingAzurophil Granule Protein 7BindingBiochemicalBiologicalBreast MetastasisBusiness-Friendly AtmosphereC-ANCAC-ANCA AntigenC-K-RASCRISPRCRISPR/Cas systemCancer PrognosisCancer cell lineCancersCell BodyCell Communication and SignalingCell Cycle ProgressionCell FunctionCell LineCell LocomotionCell MigrationCell MovementCell PhysiologyCell PolarityCell ProcessCell SignalingCellLineCellsCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessChemicalsClustered Regularly Interspaced Short Palindromic RepeatsColorectal CancerCoupledCysteineCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationCytoskeletal SystemCytoskeletonDNA mutationDataDependenceDevelopmentDiseaseDisorderDisulfidesDrug DesignDrug resistanceExhibitsFamilyGTPGTP BindingGTP PhosphohydrolasesGTP boundGTPasesGenetic ChangeGenetic defectGenetic mutationGlycineGuanine NucleotidesGuanosine PhosphatesGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHalf-CystineImpairmentIn VitroIntracellular Communication and SignalingIsoformsK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASKinasesL-CysteineLeukocyte Proteinase 3MCF-7MCF-7 CellMCF-7DRMCF-7WTMCF7MCF7 cellMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMelanomaMelanoma CellMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutationMyeloblastinN-proteinase 4NP-4NP4(3)Neoplasm MetastasisNeutrophil Proteinase 4Neutrophil Serine ProteinaseNucleotidesOncogene K-RasOncogenesisOncogenicPR-3PathologyPhenotypePhosphotransferase GenePhosphotransferasesPieranometazinePlayPrevalenceProliferatingProtein IsoformsProteinase 3ProteinsPulmonary CancerPulmonary malignant NeoplasmRASK2RNA SplicingRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSpecificitySplicingStrains Cell LinesStructureSubcellular ProcessSystemTechniquesTechnologyTestingTherapeuticTrainingTranslatingTransphosphorylasesTumorigenicityVariantVariationVesnarinoneWegener AutoantigenWegener Granulomatosis Autoantigenaminoacidbiologicbiological signal transductionbreast cancer metastasisbusiness-friendly environmentcancer metastasiscancer progressioncell immortalizationcell motilitycellular polaritychemical geneticscollaborative atmospherecollaborative environmentconformationconformationalconformational stateconformationallyconformationscultured cell linedesigndesigningdevelopmentaldrivingdrug resistantgain of functiongain of function mutationgenetic approachgenetic strategygenome mutationguanosinetriphosphatasehuman diseasein vivoinhibitorinhibitor druginhibitor therapeuticinhibitor therapyinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentinterestintracellular skeletonlung cancermalignancymembermutantneoplasm progressionneoplasm/cancerneoplastic progressionneutrophil proteinase 3p29p29bpeer-group atmospherepeer-group environmentprime editingresistance to Drugresistant to Drugrho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding Proteinsscreeningscreeningssocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltumortumor cell metastasistumor progressiontumorigenesisv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
Description preview
PROJECT SUMMARY
Rac1, a member of the Rho GTPase subfamily, regulates essential cellular functions including
cytoskeletal arrangement, cell motility, cell cycle progression, and proliferation. Dysregulation of Rac1, such as
through the oncogenic P29S mutation or the expression of the alternative splice variant Rac1b, is common in
cancer and…
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