grant

The COVID-19 pandemic: Impact on mental health and HIV outcomes

Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 20 Mar 2023Deadline 19 Mar 2027
NIHUS FederalResearch GrantFY20232019 novel corona virus2019 novel coronavirus2019-nCoVAIDSAIDS VirusAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immuno-Deficiency SyndromeAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAcquired Immunologic Deficiency SyndromeAddressAmericanAnxietyAwardBindingBipolar Affective PsychosisBipolar DisorderCOVID crisisCOVID epidemicCOVID pandemicCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 exposureCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 pandemic affectedCOVID-19 pandemic consequenceCOVID-19 pandemic effectsCOVID-19 pandemic impactCOVID-19 pandemic impactedCOVID-19 public health crisisCOVID-19 virusCOVID19COVID19 crisisCOVID19 epidemicCOVID19 global health crisisCOVID19 global pandemicCOVID19 health crisisCOVID19 pandemicCOVID19 public health crisisCOVID19 virusCV-19CV19CaringClinicalCoV-2CoV2CollaborationsDataDevelopmentDiagnosisEmergenciesEmergency SituationEpidemicEpidemiologistFailureFrequenciesFunding OpportunitiesFutureGeneral PopulationGeneral PublicGeographyGoalsHIVHealth FacilitiesHealth PolicyHealth ServicesHealth care facilityHealthcareHealthcare FacilityHospital AdmissionHospitalizationHuman Immunodeficiency VirusesIncidenceInfectionKnowledgeLAV-HTLV-IIILong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Lymphadenopathy-Associated VirusManic-Depressive PsychosisMental DepressionMental HealthMental Health ServicesMental HygieneMental Hygiene ServicesMental disordersMental health disordersMolecular InteractionMonitorMonkey PoxMonkeypoxNIMHNational Institute of Mental HealthNewly DiagnosedOutcomePersonsPharmaciesPharmacy facilityPhlebotomyPhysical distancingPoliciesPositionPositioning AttributePreparednessPsychiatric DiseasePsychiatric DisorderPsychological HealthPublic HealthReadinessRelaxationResearchResearch InfrastructureResource AllocationRiskSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 exposureSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-CoV2SARS-CoV2 epidemicSARS-CoV2 exposureSARS-CoV2 pandemicSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SchizophreniaSchizophrenic DisordersServicesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 exposureSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2Social DistanceSocial supportSubgroupSymptomsTimeTransmissionTreatment outcomeUnited StatesVenous blood samplingViralViral BurdenViral LoadViral Load resultVirus-HIVVisitVulnerable PopulationsWuhan coronavirusaccess restrictionsbipolar affective disorderbipolar diseasebipolar illnesscare facilitieschronic COVIDchronic COVID-19chronic novel coronavirus disease 2019clinical carecohortcorona virus disease 2019corona virus disease 2019 epidemiccorona virus disease 2019 pandemiccoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 exposurecoronavirus disease 2019 global health crisiscoronavirus disease 2019 global 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syndrome coronavirus 2 global pandemicsocial support networktelehealthtransmission processtreatment servicestrendvulnerable groupvulnerable individualvulnerable people
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Full Description

PROJECT SUMMARY
Approximately half of all people with HIV (PWH) in the United States (US) have one or more mental health
disorder. Ending the HIV Epidemic in the US requires addressing the mental health needs of, and
improving HIV treatment outcomes for, PWH with mental health disorders. The goal of this project is to
advance our understanding of the impact of the COVID-19 pandemic – a disruption to HIV research and care –
on the mental health and HIV treatment outcomes of PWH in the US.
The COVID-19 pandemic is a significant risk to mental health. Mental health symptoms among PWH have
been exacerbated during the COVID-19 pandemic due to physical distancing restrictions, increased material
hardship, decreased social support, concerns about COVID-19 exposure, infection and long COVID, and
disruption to mental health services. Beyond symptoms, an important question remains unanswered: “Did
COVID-19 increase the burden of diagnosed mental health disorders and/or psychiatric-related
hospitalizations in PWH?” Mitigation policies to reduce the spread of SARS-CoV-2 led to restricted access to
routine non-emergent healthcare, interfering with routine HIV monitoring and perhaps increasing
hospitalizations particularly among PWH with mental health disorders, posing the question: “Was the
frequency of unsuppressed HIV viral load and hospitalization different in PWH with (vs. without)
diagnosed mental health disorders before and during the pandemic?”
Our team consists of clinicians and epidemiologists with expertise in mental health, HIV, and COVID-19. We
propose to leverage the research infrastructure of the North American AIDS Cohort Collaboration on Research
and Design (NA-ACCORD), the largest and most diverse collaboration of longitudinal HIV cohorts in the US, to
examine the COVID-19-related impact on mental health and HIV treatment outcomes. The specific aims for
this 3-year project are:
Aim 1: To examine trends and differences in the incidence rates of mental health diagnoses and
psychiatric-related hospitalizations among PWH in the US before and during the COVID-19 pandemic.
Aim 2. Aim 2. To evaluate the extent to which mental health- disparities in the rates of unsuppressed
HIV viral load and all-cause hospitalization widened during the COVID-19 pandemic among PWH.
This study directly addresses the priorities of the National Institute of Mental Health in the funding opportunity
Urgent Award: COVID-19 Mental Health Research (PAR-22-113). Our aims will rapidly generate critical
evidence of the impact of the COVID-19 pandemic on the mental health and HIV treatment outcomes among
PWH in the US (overall and within 9 key subgroups), inform strategies to mitigate such impacts on PWH during
and after the COVID-19 pandemic, and improve preparedness for future public health emergencies.

Grant Number: 1RF1MH133427-01
NIH Institute/Center: NIH
Principal Investigator: Keri Althoff

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