grant
The contribution of HSV-2 ICP34.5 variation to neurovirulence during neonatal infection
Organization LURIE CHILDREN'S HOSPITAL OF CHICAGOLocation CHICAGO, UNITED STATESPosted 7 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAdultAdult HumanAnti-viral TherapyAutomobile DrivingBindingBinding ProteinsBirthBrainBrain InflammationBrain Nervous SystemBuccal CavityBuccal Cavity Head and NeckCNS DiseasesCNS disorderCNS infectionCavitas OrisCell BodyCell Culture TechniquesCellsCentral Nervous System DiseasesCentral Nervous System DisordersCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCerebromeningitisCharacteristicsChildChild YouthChildren (0-21)ClinicalComparative Genomic AnalysisComplexCore FacilityDataDefectDevelopmentDiseaseDisorderEctopic ExpressionEnabling FactorsEncephalitisEncephalomeningitisEncephalonEye InfectionsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGenesGenetics-MutagenesisGoalsHHV-2HHV2HSVHSV encephalitisHSV-1HSV-2HSV1HSV2Herpes SimplexHerpes Simplex EncephalitisHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex VirusHerpes Simplex Virus 1Herpes Simplex Virus 2Herpes Simplex Virus Type 1Herpes Simplex Virus Type 2Herpes encephalitisHerpes labialis VirusHerpes simplex diseaseHerpesvirus 1Herpesvirus 2 (alpha), HumanHerpesvirus hominis diseaseHerpesvirus progenitalisHerpetic EncephalitisHourHumanHuman (alpha) herpes virus 2Human Herpesvirus 2Human herpes simplex virus type 2ImmuneImmune EvasionImmune responseImmunesImmunityIn VitroIndividualInfantInfectionInfectious Skin DiseasesInjectionsInnate ImmunityIsoformsKnowledgeLengthLigand Binding ProteinLigand Binding Protein GeneMeningoencephalitisMiceMice MammalsModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMouthMurineMusMutagenesisMutagenesis Molecular BiologyNative ImmunityNatural ImmunityNeonatalNervous System DiseasesNervous System DisorderNeuroimmuneNeurologicNeurologic DeficitNeurologic DisordersNeurologic outcomeNeurologicalNeurological DisordersNeurological outcomeNon-Specific ImmunityNonspecific ImmunityOcular InfectionsOral cavityOutcomeParturitionPathogenicity FactorsPathway interactionsPlasmidsPredispositionProtein BindingProtein IsoformsProteinsRNA SplicingRNA StabilityRegulationSimplexvirusSingle-Nucleus SequencingSplicingStimulator of Interferon GenesSusceptibilityTestingTimeTransfectionVariantVariationViralViral DiseasesViral GenomeVirulence FactorsVirusVirus DiseasesWorkadaptive immunityadulthoodanti-viral developmentanti-viral drug developmentanti-viral therapeutic developmentanti-viral therapy developmentantiviral developmentantiviral drug developmentantiviral therapeutic developmentantiviral therapy developmentbound proteincGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcell culturecell culturescell typeclinical relevanceclinically relevantcutaneous infectioncyclic GMP-AMP synthase/STINGdeveloping anti-viral agentdeveloping anti-viral drugdeveloping anti-viral therapeuticdeveloping anti-viral therapydeveloping antiviral agentdeveloping antiviral drugdeveloping antiviral therapeuticdeveloping antiviral therapydevelopmentaldrivingentire genomeexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfull genomegenomic variationherpes simplex iherpes simplex iiherpes simplex virus 1 encephalitisherpes simplex virus 1 infectionherpes simplex virus encephalitisherpes simplex virus infectionherpes simplex-1host responsehuman alphaherpesvirus 2immune evasiveimmune system responseimmunoresponsein vivoinfant infectioninfected infantinfected neonateinfected newborninfected skinintervention designkidsmouse modelmurine modelmutantneonatal brainneonatal infectionneonateneurological diseaseneuroprotectionneuroprotectiveneurovirulencenew approachesnewborn infectionnovelnovel approachesnovel strategiesnovel strategypathwayposttranscriptionalpreventpreventingprotein expressionresponsesNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqskin infectionsnRNA sequencingsnRNA-seqtherapy designtreatment designviral genomicsviral infectionviral infectious disease treatmentvirus genomevirus genomicsvirus infectionvirus-induced diseasewhole genomeyoungster
Description preview
PROJECT SUMMARY / ABSTRACT
Herpes simplex virus (HSV)-2 infection of the neonatal brain causes severe meningoencephalitis and
permanent neurologic deficits. However, infants infected with HSV-2 at the time of birth follow different clinical
courses. Some infants develop only external infection of the skin, eyes, or mouth (SEM disease), while…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click