grant
The contribution folate and vitamin B12 genes to disease.
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AffectAffinityAgeAminoacetic AcidAnemiaAnimal ModelAnimal Models and Related StudiesAnimalsApplied GeneticsAssayBindingBioassayBioavailabilityBioinformaticsBiologicalBiological AssayBiological AvailabilityBiologyBirth DefectsBloodBlood Reticuloendothelial SystemBody TissuesBrachydanio rerioBrainBrain Nervous SystemCancersCannot achieve a pregnancyCarbonCardiac DiseasesCardiac DisordersCaringCarrier ProteinsCell BodyCell divisionCellsCellular ExpansionCellular GrowthChiro-InositolCholineCirculationClinicalClinical EvaluationClinical TestingCobalamin-Binding ProteinsCodeCoding SystemCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort StudiesCollaborationsConcurrent StudiesCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCyanocobalaminDNADNA MethylationDanio rerioDataDefectDeoxyribonucleic AcidDepositDepositionDevelopmentDietDifficulty conceivingDiseaseDisorderDisturbance in cognitionEmbryoEmbryonicEncephalonEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEquilibriumExhibitsFamilyFemaleFishesFolateFolic AcidFolic Acid DeficiencyFormatesFrequenciesFundingFutureGWA studyGWASGene ExpressionGene variantGenesGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic ResearchGenetic SusceptibilityGenetic VariationGenetic propensityGenomicsGenotypeGestationGlycineGoalsHair ColorHealthHeart DiseasesHereditaryHomocysteineHumanHuman GenomeImpaired cognitionIndividualInfertilityInheritedInherited PredispositionInherited SusceptibilityInjectionsInner mitochondrial membraneInositolIntermediary MetabolismInternationalInvestigatorsKnock-outKnockoutLengthLiteratureLiverLocationMalignant NeoplasmsMalignant TumorManuscriptsMeasuresMesoinositolMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethionineMethodsMethylmalonic AcidMiceMice MammalsMicronutrientsMitochondriaMitochondrial DNAModelingModern ManMolecular InteractionMurineMusNervous System PhysiologyNeural Tube DefectsNeural Tube Developmental DefectsNeural tubeNeurologicNeurologic functionNeurologicalNeurological functionNormal RangeNormal ValuesNutrientNutritionalOther GeneticsOvulationParticipantPathway interactionsPhenotypePhysiologic AvailabilityPlantsPopulationPregnancyProcessProteinsPteroylglutamic AcidPublishingPyridoxinPyridoxolReportingResearchResearch PersonnelResearchersRetinaRiskRoleSample SizeSamplingSchistorrhachisSideSpina BifidaSpinal DysraphiaSpinal DysraphismSystemTechnologyTestingTimeTissuesTranscobalaminsTransport Protein GeneTransport ProteinsTransporter ProteinVIT B12VIT B6VariantVariationVitamin B 12Vitamin B 12 DeficiencyVitamin B 12-Binding ProteinsVitamin B 6Vitamin B12Vitamin B12 DeficiencyVitamin B12-Binding ProteinsVitamin B6Vitamin MWorkZebra DanioZebra FishZebrafishagesallelic variantanxious behaviorbalancebalance functionbiologiccase controlcase-controlledcell growthcellular targetingcholine transportercirculating biomarkerscirculating markerscleft spineclinical testcognitive dysfunctioncognitive losscohortcollegecollegiatecostdevelopmentaldietarydietsentire genomeenvironmental riskexperimentexperimental researchexperimental studyexperimentsfertility cessationfertility lossfetal nutritionfetus nutritionfolate deficiencyfull genomegenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic variantgenotyping technologyheart disorderhepatic body systemhepatic organ systemheteroplasmyhigh-affinity choline transporterhuman whole genomehydrocele spinalisimplantationimprovedinfertileinsightmalignancymelanocytemethyl-propanedioic acidmitochondrialmodel of animalmouse modelmtDNAmurine modelneoplasm/cancernervous system functionnutritiousoffspringpathwaypyridoxinerachischisis posteriorrecruitresearch clinical testingsocial roletumoruptakevitamin Bcvitamin receptorwhole genomewhole genome association analysiswhole genome association study♀
Description preview
Research in the Gene and Environment Interaction Section is focused on defining changes in the genes that underlie inherited susceptibilities to common diseases such as cancer and birth defects. Changes in folate and vitamin B12 metabolism are associated with tumor formation, birth defects and cognitive decline. Folate and vitamin B12 genes are…
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