grant
The cause of Estrogen Deficiency-Induced Insulin Resistance
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 13 Mar 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20261,2,3-Propanetriol1,2,3-TrihydroxypropaneAdipose tissueAdrenergic AgentsAdrenergic DrugsAdrenergicsAttenuatedAutomobile DrivingBlood PlasmaBody TissuesBrainBrain Nervous SystemCancersCardiovascular DiseasesDevelopmentDrug TherapyDysfunctionEmploymentEncephalonEstrogen Replacement TherapyEstrogen ReplacementsEstrogen deficiencyEstrogensFatty AcidsFatty LiverFatty TissueFemaleFree Fatty AcidsFunctional disorderGlycerinGlycerolGonadal Steroid HormonesHealthHepaticHepatic TissueHumulin RImpairmentInflammationInsulinInsulin ResistanceInterventionLevarterenolLevonorepinephrineLinkLipolysisLiteratureLiverLiver SteatosisMalignant NeoplasmsMalignant TumorMenopauseMetabolicMetabolic ControlMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMetabolic syndromeMiceMice MammalsModelingMurineMusNerveNonesterified Fatty AcidsNoradrenalineNorepinephrineNovolin RNutrientObesityOophorectomyOrganOvariectomyPeripheralPharmacological TreatmentPharmacotherapyPhysiopathologyPlasmaPlasma SerumPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePropertyRegular InsulinResistanceReticuloendothelial System, Serum, PlasmaRiskRodentRodentiaRodents MammalsRoleSex HormonesSex Steroid HormonesSympathetic Nervous SystemSympathetic-Blocking AgentsSympatholytic AgentsSympatholytic DrugsSympatholyticsTestingTherapeuticTherapeutic EstrogenThesaurismosisTissuesWomanadiposeadiposityafter menopauseattenuateattenuatesblood glucose regulationcancer riskcardiovascular disordercorpulencedeficiency in estrogendevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesitydrivingdrug interventiondrug treatmenteffective interventionfemale gonadectomyfollowing menopausegain of functionglucose RAglucose controlglucose homeostasisglucose productionglucose rate of appearanceglucose regulationgonadal steroidshepatic body systemhepatic organ systemhepatic steatosishepatosteatosisimprovedinnovateinnovationinnovativeinsightinsulin resistantinsulin sensitivityinsulin signalinginsulin toleranceloss of functionmalemalignancymetabolism disordermouse modelmurine modelneoplasm/cancerpast menopausepathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-menopausalpostmenopausalpostmenopausal statuspreventpreventingresistantsexsex steroidsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentwhite adipose tissueyellow adipose tissue♀♂
Description preview
Menopause and estrogen deficiency increase the risk of insulin resistance and metabolic diseases
in women, but the mechanisms remain unclear. Targeted therapies for menopause associated
insulin resistance are lacking, with estrogen replacement increasing the risk of certain
malignancies. Estrogen deficiency leads to sympathetic nervous system…
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