grant

The Black American United Memory & Aging Project (BA-UMAP): An examination of cognitive decline in midlife and older Black adults using remote cognitive assessments, risk factors & biomarkers

Organization NORTH CAROLINA AGRI & TECH ST UNIVLocation GREENSBORO, UNITED STATESPosted 1 Sept 2022Deadline 31 May 2027
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD related dementiaADRDAccelerationActive Follow-upAdultAdult HumanAffectAgeAge YearsAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAreaAssessment instrumentAssessment toolBehavioralBiologic FactorBiologicalBiological FactorsBiological MarkersBiomedical ResearchBlackBlack AmericanBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBlood VesselsCausalityCell PhoneCellular PhoneCellular TelephoneClinicalClinical ResearchClinical StudyCognitiveCognitive DiscriminationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionComputersDataData CollectionDevelopmentDiagnosisDietDiscriminationDiseaseDisorderDisturbance in cognitionEarly DiagnosisEducation and OutreachEducational AchievementEducational StatusEnrollmentEnvironmental FactorEnvironmental Risk FactorEtiologyFamilyFamily Medical HistoryFamily Medical History EpidemiologyFamily history ofFearFosteringFoundationsFrightFutureGeneticGeographyGoalsHabitsHealthHealth StatusHigh PrevalenceHistoryImpaired cognitionIndividualIndividual DifferencesInflammationInflammatoryInstruction and OutreachInternetLengthLevel of HealthLife StyleLifestyleLow incomeMeasuresMemoryMental DepressionMethodologyMethodsMinorityMobile PhonesModalityNeighborhoodsOutcomeParticipantPatient Self-ReportPopulationPrevalencePrimary Senile Degenerative DementiaPrivatizationQuestionnairesRecording of previous eventsReligiosityReportingResearchResearch SpecimenRiskRisk FactorsRisk ReductionSalivaSalivarySamplingSelf EfficacySelf-ReportSpecimenStigmatizationStressTestingTimeTraining and OutreachTransportationTrustTutoring and OutreachUncertaintyUrineVascular DiseasesVascular DisorderWWWWorkactive followupadulthoodagedagesalzheimer riskbio-markersbiologicbiologic markerbiomarkerbiopsychosocial factorbiopsychosocial variableblack femaleblack maleblack manblack menblack womenblood vessel disorderbrain healthcardiometaboliccardiometabolismcausationcognitive assessmentcognitive changecognitive dysfunctioncognitive functioncognitive losscognitive testingcohesioncohortcollegecollegiatecommunity level disadvantagecostdepressiondeprivationdevelopmentaldietsdigital mediadisadvantaged communitydisease causationdisparity in healthdoubtearly detectioneducational levelenrollenvironmental riskethnic minorityexecutive controlexecutive functionfollow upfollow-upfollowed upfollowuphandheld mobile devicehealth determinantshealth disparityhealth levelhealth literacyhistoriesiPhoneimprovedindexingindividual heterogeneityindividual variabilityindividual variationinnovateinnovationinnovativelack of physical activitymid lifemid-lifemiddle agemiddle agedmidlifeminority healthmobile appmobile applicationmobile devicemobile device applicationneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantagenew approachesnovelnovel approachesnovel strategiesnovel strategyon-line communityonline communityphysical inactivitypreferencepreventpreventingprimary degenerative dementiaprocessing speedprospectiveprotective factorsracial minorityrecruitreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskremote administrationremote assessmentremote evaluationresearch studyresilience factorresiliency factorrisk-reducingsample collectionscreeningscreeningssenile dementia of the Alzheimer typesmart phonesmartphonesocialsocial culturesocial engagementsocial involvementsocial participationsocio-culturalsocio-economicsocio-economicallysocioculturalsocioeconomicallysocioeconomicsspecimen collectionstressortelomeretooltraining achievementtraining leveltraining statusvascularvascular dysfunctionvasculopathyvirtual communitywebworld wide web
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Full Description

More research on the multi-level factors impacting the higher prevalence of Alzheimer’s disease and related dementias among Black adults is critically needed. The overall goal of this project is to increase our understanding of the biopsychosocial factors that impact cognitive outcomes in a cohort of 600 longitudinally followed middle-aged and older Black adults (aged 55+). This cohort, referred to as the Black American United Memory and Aging Project (BA-UMAP), will be established and maintained remotely using an innovative online, faceless enrollment and data collection strategy, and will involve: (a) a comprehensive assessment of biopsychosocial factors through online questionnaires; (b) annual cognitive assessments, administered remotely via computer and mobile devices; (c) the remote collection of non-invasive saliva and urine samples at baseline and Year 4; and (d) the utilization and integration of digital media platforms for creating a virtual community that provides outreach and education, and fosters trust. The overall objectives of this study are to: (1) prospectively evaluate cognitive functioning and identify preferences for remote cognitive assessment modalities; (2) identify sociocultural, behavioral, and environmental factors associated with cross-sectional cognitive functioning and longitudinal cognitive decline, and (3) examine the association of acquired biological risk factors, inclusive of family and health history, and salivary and urine biomarkers, to cognitive functioning and cognitive decline.

This research is a necessary step in understanding the etiology of cognitive decline and, for informing future strategies for early detection and support for the development of remote methodologies for longitudinal brain health research among middle aged to older Black adults.

Grant Number: 5R01AG079388-04
NIH Institute/Center: NIH
Principal Investigator: Travonia Brown-Hughes

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