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The action of DDR2 in cancer-associated fibroblasts promotes ovarian cancer metastasis through increased arginase-1 activity.
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2023Deadline 12 May 2025 ⚠️
NIHUS FederalResearch GrantFY20252,5-Diaminopentanoic AcidAbdomenAnabolismArchitectureArginineAssayBioassayBiological AssayBreast CancerCancer PatientCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell-Extracellular MatrixCellsCellular ProliferationChemoresistanceCollagenDDR2 ProteinDDR2 kinaseDataDepositDepositionDevelopmentDiffusionDiscoidin Domain Receptor Family Member 2ECMEngineering / ArchitectureEnvironmentEnzyme GeneEnzymesExtracellular MatrixFemale Genital DiseasesFibrillar CollagenFibroblastsFutureGeneralized GrowthGreater sac of peritoneumGrowthGynecologic DiseasesHepatic Proliferation InhibitorHumanIn VitroKnock-outKnockoutL arginine amidinohydrolaseL-ArginineL-Ornithine carboxy-lyaseL-ProlineLiver Immunoregulatory ProteinLiver-Derived Inhibitory ProteinMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Pancreatic NeoplasmMalignant TumorMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of pancreasManuscriptsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMesenchymalMesothelial CellMesotheliumMetabolicMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModern ManMolecularMurineMusNeoplasm MetastasisOmental FatOmentumOrganOrnithineOrnithine Carboxy-lyaseOrnithine DecarboxylaseOvarianOvarian TumorOvary CancerOvary NeoplasmsOvary TumorPTK ReceptorsPancreas CancerPancreatic CancerPatternPeritonealPeritoneal CavityPhysiciansPlayPolyamine CompoundPolyaminesProductionProlinePulmonary CancerPulmonary malignant NeoplasmReceptor Protein-Tyrosine Kinase TKTReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReceptor-Related 3 Neurotrophic Tyrosine KinaseRegulationRoleScientistSecondary NeoplasmSecondary TumorSerousSourceStage at DiagnosisStromal CellsStromal NeoplasmStromal TumorTestingTherapeutic InterventionTissue GrowthTrainingTransmembrane Receptor Protein Tyrosine KinaseTumor BurdenTumor CellTumor Cell InvasionTumor InvasionTumor LoadTyrosine Kinase Linked ReceptorsTyrosine Kinase Receptor Related to Neurotrophic TRKTyrosine Kinase ReceptorsTyrosine-Protein Kinase TYRO 10arginasearginine amidinasebiosynthesiscanavanasecancer cellcancer metastasiscancer microenvironmentchemoresistantchemotherapy resistancechemotherapy resistantdevelopmentaldiffuseddiffusesdiffusingdiffusionsdiscoidin domain receptor 2in vivointervention therapyintraperitoneallung cancermRNA sequencingmRNA-seqmRNAseqmalignancymalignant breast tumormetastatic processmouse modelmurine modelneoplasm/cancerneoplastic cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyovarian cancerovarian neoplasmoverexpressoverexpressionpancreatic malignancyparacrinereceptor bindingreceptor boundresponseresponse to therapyresponse to treatmentshRNAshort hairpin RNAsmall hairpin RNAsocial roletherapeutic agent developmenttherapeutic developmenttherapeutic responsetherapy responsetreatment responsetreatment responsivenesstumortumor cell metastasistumor growthtumor microenvironmenttyrosine kinase receptor type 10
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Description preview
SPECIFIC AIMS
Ovarian cancer is the most lethal gynecological disease. 70-80% of ovarian cancer patients are diagnosed at
stage III or IV when peritoneal metastasis has already occurred. The unique metastasis pattern in ovarian cancer
involves the detachment of tumor cells, diffusion through the intraperitoneal space and attachment to the…
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