grant
TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and Tolerance
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntigensApoptosisApoptosis PathwayApoptoticAttentionAutoimmune DiseasesAutoimmune StatusAutoimmunityBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBone-Derived Transforming Growth FactorBrittle Diabetes MellitusBuccal CavityBuccal Cavity Head and NeckBuccal MucosaCCR8CCR8 geneCD25CKR-L1CKRL1CMKBR8CMKBRL2CY6CancersCavitas OrisCell BodyCell Communication and SignalingCell SignalingCellsCommunicable DiseasesD-MannoseDendritic CellsDevelopmentDiseaseDisorderEYDFFOXP3FOXP3 geneForkhead Box P3GEM modelGEMM modelGPR-CY6General Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetically Engineered MouseGestationGlycolysisGoalsHumanIDDMIL2RIL2RAIL2RA geneImmune ToleranceImmunityImmunologic ToleranceImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectious DiseasesInfectious DisorderInflammationInsulin-Dependent Diabetes MellitusIntermediary MetabolismIntracellular Communication and SignalingJM2Juvenile-Onset Diabetes MellitusKO miceKetosis-Prone Diabetes MellitusKnock-out MiceKnockout MiceKnowledgeLung InflammationLymphatic TissueLymphatic cellLymphocyteLymphocyticLymphoidLymphoid TissueMacrophageMaintenanceMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMannopyranoseMannopyranosideMannoseMediatingMetabolic ProcessesMetabolismMilk Growth FactorMissionModern ManMolecularMouthMouth CancerMouth MucosaMucosaMucosal TissueMucous MembraneMφNIDCRNIDRNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchNull MouseOral CancerOral MucosaOral cavityOral mucous membrane structurePathogenesisPathway interactionsPeptidesPeripheralPlatelet Transforming Growth FactorPlayPneumonitisPregnancyProductionProgrammed Cell DeathPsoriasisPulmonary InflammationRegulationRegulatory T-LymphocyteResearchRoleSCURFINSepsisSignal TransductionSignal Transduction SystemsSignalingSudden-Onset Diabetes MellitusSystemT cell regulationT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMTCGFRTER1TGF BTGF-betaTGF-beta ReceptorsTGF-βTGF-β ReceptorsTGFbetaTGFβTherapeutic InterventionThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor beta ReceptorsTransforming Growth Factor β ReceptorsTransforming Growth Factor-Beta Family GeneTregType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVeiled CellsWound Repairactivin Aautoimmune conditionautoimmune disorderautoimmune inflammationautoimmunity diseasebiological signal transductiondesigndesigningdevelopmentalerythroid differentiation factorerythroid differentiation proteingenetically engineered mouse modelgenetically engineered murine modelhomo-activin Ahuman diseaseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinsulin dependent diabetesinsulin dependent type 1interestintervention therapyintraepithelialjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslymph cellmalignancymalignant mouth neoplasmmalignant mouth tumormodel of animalmouse modelmurine modelneoplasm/canceroral cavity canceroral mucosaeoral mucosalpathwaypsoriasiformpsoriaticregulatory T-cellssocial rolethymus derived lymphocytetranscription factortumortype I diabetestype one diabeteswound healingwound recoverywound resolution
Description preview
Our research interest is to elucidate mechanisms of TGF-beta regulation of mucosal and systemic T cell immunity and tolerance, in order to offer targets to manipulate T cell immunity versus tolerance in animal models to develop potential therapies for relevant human diseases such as autoimmunity, cancer and infectious diseases. Specifically we…
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