grant
Tfh Cell Plasticity and Heterogeneity in Shaping Immune Responses to Allergy, Infection, and Tolerance
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AblationAddressAllergensAllergicAllergic DiseaseAllergic inflammationAllergic to foodAllergyAllergy to foodAntibodiesAntibody ResponseAntigensAtrophic ArthritisAutoantibodiesAutoimmune DiseasesAutoimmune StatusAutoimmunityAutoregulationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBlood Plasma CellCD152CD152 AntigenCD152 GeneCD154CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD40LCD40LGCTLA 4CTLA-4 GeneCTLA4CTLA4 deficiencyCTLA4 geneCTLA4 haploinsufficiencyCTLA4-TMCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell DifferentiationCell Differentiation processCell SignalingCellsCellular biologyClinical DataCo-StimulatorColitisCollaborationsComplexCostimulatorCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DataDevelopmentDiseaseDisorderDoseDysfunctionEpidermal Thymocyte Activating FactorEquilibriumExposure toFailureFood AllergyFood HypersensitivityFoundationsFunctional disorderFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGerminal CenterGoalsGut associated lymphoid tissueHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeterogeneityHomeostasisHumanIL-2IL2 ProteinIL21IgEImmuneImmune mediated therapyImmune responseImmunesImmunityImmunoglobulin EImmunologically Directed TherapyImmunologyImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImpairmentInducer CellsInducer T-LymphocytesInfectionInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IIInterventionIntestinalIntestinesIntracellular Communication and SignalingKnowledgeLinkLungLung Respiratory SystemLupusLupus Erythematosus DisseminatusLymphocyte Mitogenic FactorMapsMediatingMemoryMemory B CellMemory B-LymphocyteMitogenic FactorModelingModern ManModificationMolecularMucosaMucosal TissueMucous MembraneNIAIDNIDDKNational Institute of Allergy and Infectious DiseaseNational Institute of Diabetes and Digestive and Kidney DiseasesNatureOutcomeP50 MechanismP50 ProgramPathogenicityPathologyPathway interactionsPatientsPhysiological HomeostasisPhysiopathologyPlasma CellsPlasmacytesPopulationPre-Clinical ModelPreclinical ModelsProductionRecombinantsRegulatory T-LymphocyteRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderRheumatoid ArthritisRoleSLEScienceShapesSignal TransductionSignal Transduction SystemsSignalingSourceSpecialized CenterStem Cell likeStructureStructure of germinal center of lymph nodeSupporting CellSystemSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusSystemic diseaseT cell growth factorT-Cell Growth FactorT-Cell Stimulating FactorT-CellsT-LymphocyteT4 CellsT4 LymphocytesTNFSF5TNFSF5 geneTRAP GeneTeff cellTh-2 CellTh2 CellsTherapeuticTherapeutic EffectThymocyte Stimulating FactorTranscription Factor Proto-OncogeneTranscription factor genesTregType 2 Helper CellViralWorkautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive antibodyautoreactivitybalancebalance functionbiological signal transductionbowelcell biologycellular differentiationchronic autoimmune diseaseconditional knock-outconditional knockoutcytokinecytotoxic T-lymphocyte antigen 4data modelingdesensitizationdevelopmentaldisseminated lupus erythematosusdraining lymph nodeeffective therapyeffective treatmenteffector T cellgastrointestinalhost responseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic reactivity controlimmunomodulatoryimmunopathologyimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprintin vivoinflammatory disease of the intestineinflammatory disorder of the intestineinhibitorinterleukin-21intestinal autoinflammationlupus prone micelymph organlymphatic organlymphoid organmicrobial consortiamicrobial floramicrobiotamicrofloramodel of datamodel the datamodeling of the datamouse modelmultispecies consortiamurine modelmutein 2new therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayplasmocytepreservationpreventpreventingprogenitor capacityprogenitor cell likeprogenitor-likeprogramsrational designrecombinant Mut2 proteinregional lymph noderegulatory T-cellsrespiratoryresponserheumatic arthritisself reactive antibodysingle cell analysissocial rolestem cell characteristicsstem-likestemnesssuccesssystemic autoimmunitysystemic lupus erythematosistargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetooltranscription factor
Description preview
T follicular helper (Tfh) cells are a subset of CD4⁺ T cells that support B cells within germinal centers (GCs)—specialized structures in lymphoid organs where B cells refine their antibodies and generate long-lived plasma cells and memory B cells. By providing key signals through molecules such as CD40L and cytokines like IL-21, Tfh cells drive…
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