grant

Tetramer Research & Development Contract (Influenza)

Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 21 Mar 2020Deadline 20 Mar 2027
NIHUS FederalResearch GrantFY2022Antigen Presentation PathwayAntigen Processing and PresentationAreaBar CodesBinding SitesBiotinClass II GenesCombining SiteCommunicable DiseasesCommunitiesContracting OpportunitiesContractsCore FacilityDNADeoxyribonucleic AcidDevelopment and ResearchDiseaseDisorderGolden HamstersGolden Syrian HamstersGrippeHLA Class II GenesImmuneImmunesImmunologyInfectious Disease PathwayInfectious DiseasesInfectious DisorderInfluenzaInfluenza VirusMHC Class IIMHC Class II GenesMediatingMesocricetus auratusNational Institutes of HealthOligoOligonucleotidesPerformanceProductionR & DR&DReactive SiteReagentResearchResearch ResourcesResourcesStaining methodStainsStrepavidinStreptavidinSyrian HamstersT cell responseT-Cell ActivationT-CellsT-LymphocyteTechnologyTimeTumor CellUnited States National Institutes of HealthVariantVariationVitamin Hbarcodecoenzyme Rcostfluorophoreinfluenzavirusmicrobe pathogenmicrobial pathogenneoplastic cellnoveloligospathogenic microberesearch and developmentthymus derived lymphocyte
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Full Description

The NIH Tetramer Core Facility provides valuable resources to the research community that enable cutting edge research in basic immunology and a wide variety of infectious disease areas (including the influenza virus) via production and distribution of class I, class II and CD1 reagents. The reagents are being applied to studies of antigen processing and presentation, T cell activation, T cell responses against microbial pathogens or tumors, and T cell-mediated exacerbation or amelioration of immune-mediated diseases. This contract conducts research and development that would enhance the quality, functionality (e.g., sensitivity), and breadth of available tetramer reagents and decrease production time.

Grant Number: 75N93020D00005-0-759302200001-3
NIH Institute/Center: NIH
Principal Investigator: JOHN ALTMAN

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