grant
Telomerase RNP Prisonbreaks from Phase-Separated Nuclear Body
Organization RESEARCH INST OF FOX CHASE CAN CTRLocation PHILADELPHIA, UNITED STATESPosted 1 Jul 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AcuteAddressAgingAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAutoregulationBindingCAR T cellsCAR modified T cellsCAR-TCAR-TsCancer DrugCancer InductionCancersCatalysisCell AgingCell SenescenceCell TherapyCellular AgingCellular SenescenceChemicalsDNA mutationDegenerative DisorderDiseaseDisorderDysfunctionEC 2.7.7.49EndowmentEngineeringEnzyme GeneEnzymesFunctional RNAFunctional disorderGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsGrowthHomeostasisHypermethylationKnowledgeLengthLinkLocationLow Molecular Weight Nuclear RNALytotoxicityMalignant NeoplasmsMalignant TumorModelingMolecularMolecular InteractionMonitorMotor CellMotor NeuronsMutationNeoplastic Disease Chemotherapeutic AgentsNon-Polyadenylated RNANoncoding RNANontranslated RNANuclearOrganellesOrganismPhasePhysiological HomeostasisPhysiopathologyPlayProgenitor CellsProtein TraffickingProteinsQuality ControlRNARNA ConformationRNA Gene ProductsRNA SplicingRNA TranscriptaseRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseReplicative SenescenceResistanceReverse TranscriptaseRevertaseRibonucleic AcidRibonucleoproteinsRoleSightSmall Molecular Weight RNASmall Nuclear RNASplicingStructureSystemT cells for CARTelomeraseTelomerase RNA ComponentTelomerase inhibitionTestingTissue GrowthTumor-Specific Treatment AgentsUntranslated RNAVisionaging associatedaging relatedanti-cancer drugcarcinogenesiscell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscombatcytotoxicitydegenerative conditiondegenerative diseasedriver lesiondriver mutationexhaustiongenome mutationgenotoxicityhallmarks of agingimprovedinsightliving systemmalignancymotoneuronneoplasm/cancernoncodingnovelontogenyoptogeneticspathophysiologypillars of agingpromoterpromotorprotein transportreplicative agingresistantsnRNAsocial rolestem cellstelomerase RNAtelomeretooltraffickinguRNAvisual function
Description preview
Project Summary
Overview: The ribonucleoprotein enzyme telomerase maintains telomere length homeostasis – a shared
hallmark between aging and carcinogenesis. Insufficient telomerase leads to telomere dysfunctions and
replicative senescence in stem cells, precipitating short-telomere diseases. Conversely, telomerase is exploited
by ~90% of cancers…
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