grant
Targeting the Microenvironment/Oncogene Cooperation to treat poor prognosis T-ALL
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 9 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026ASP-1Acute Lymphoblastic LeukemiaAcute Lymphocytic LeukemiaAcute Lymphoid LeukemiaAcute T Cell LeukemiaAcute T-Cell Lymphoblastic LeukemiaAcute T-Cell Lymphocytic LeukemiaAcute T-Lymphocytic LeukemiaAffectAnthracyclineApoptosisApoptosis PathwayAsparaginase IIAsparagine DeaminaseAssayB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2BCL2BCL2 geneBasal Transcription FactorBasal transcription factor genesBcl-2BioassayBiological AssayBiologyCD127CD127 AntigensCDW127CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCTXCYCLO-cellCancer GenesCancer-Promoting GeneCarloxanCas nuclease technologyCell BodyCell Communication and SignalingCell CycleCell Division CycleCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCell modelCellLineCellsCellular ProliferationCellular modelCessation of lifeChildhoodChildhood CancersCiclofosfamidaCiclofosfamideCicloxalClafenClapheneClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColaspaseCompensationCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanDNA mutationDataDeathDevelopmentDexamethasoneEMSAElsparEndoxanEndoxanaEnduxanEventExhibitsFBL1FBXL1FLB1FeedbackFosfaseronFoundationsGene InactivationGene SilencingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenoxalGenuxalGrowth AgentsGrowth FactorGrowth SubstancesHumanIL-7IL-7 GeneIL-7 ReceptorsIL-7R alpha chainIL-7R-alphaIL-7RalphaIL-7RαIL7IL7 ProteinIL7 ReceptorsIL7 geneIL7RIL7R geneImpairmentInterleukin 7 PrecursorInterleukin 7 Precursor GeneInterleukin 7 ReceptorInterleukin 7 Receptor AlphaInterleukin-7Interleukin-7 GeneInterruptionIntracellular Communication and SignalingKidrolaseL asparagine amidohydrolaseL-ASPL-AsparaginaseLcf-ASPLeadLedoxinaLeukemic CellLigandsLinkLymphopoietin-1MGC1366MGF proteinMGSNF proteinMaintenanceMalignantMalignant - descriptorMalignant Childhood NeoplasmMalignant Childhood TumorMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant childhood cancerMapsMeasuresMediatingMediatorMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoMiceMice MammalsMitoxanModelingModern ManMolecularMolecular AnalysisMolecular TargetMurineMusMutationNeosarNotch Signaling PathwayOncogenesOncogenesisOncogenicOutcomePDX modelPathway interactionsPatient derived xenograftPatientsPb elementPhosphorylationPlayPre-Clinical ModelPreclinical ModelsPrecursor Cell Lymphoblastic LeukemiaPrecursor Lymphoblastic LeukemiaPrecursor T Lymphoblastic LeukemiaProcytoxPrognosisProgrammed Cell DeathProliferatingProtein PhosphorylationProteins Growth FactorsProteolysis and Signaling Pathway of NotchPublic HealthRNA ExpressionRecurrent diseaseRefractoryRefractory DiseaseRegulationRelapseRelapsed DiseaseResearchRoleSKP2SKP2 geneSTAT3STAT3 geneSTAT5STAT5ASTAT5A geneSTAT5a Transcription FactorSamplingSendoxanSerasaSignal Transducer and Activator of Transcription 5ASignal TransductionSignal Transduction SystemsSignalingStat5 proteinStat5a proteinStat5alpha proteinStrains Cell LinesSurfaceSurvival RateSyklofosfamidT-Cell LeukemiaT-Cell Lymphocytic LeukemiaT-Cell Type Acute LeukemiaT-CellsT-LymphocyteT-Lymphocytic LeukemiaT-lineage acute lymphoblastic leukemiaTestingTherapeuticTherapeutic InterventionTranscriptionTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTranscriptional ControlTranscriptional RegulationTransforming GenesWorkZytoxanacute lymphatic leukemiaacute lymphogenous leukemiaacute lymphomatic leukemiaalpha chain interleukin-7 receptorasparaginaseassess effectivenessbcl-2 Genesbiological signal transductionc mycc-myc Genescancer in a childcancer in childrencancer typeced9 homologchemotherapychild with cancerchildhood malignancycmyccultured cell linedetermine effectivenessdevelop therapydevelopmentaldisease modeldisorder modeleffective therapyeffective treatmenteffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessgain of function mutationgenome mutationheavy metal Pbheavy metal leadimprovedinhibitorinsightintervention developmentintervention therapyknowledgebaseleukemialeukemia initiating cellleukemia relapseleukemia/lymphomaleukemogenesislymphoma/leukemiamammary gland factormammary gland-specific nuclear factormolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynotchnotch proteinnotch receptorsnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetoverexpressoverexpressionpathwaypatient derived xenograft modelpediatricpediatric cancerpediatric malignancypharmacologicpre-clinicalpreclinicalpromoterpromotorrecurrent leukemiasignal tranducer and activator of transcription 5social rolesuccesstherapy developmentthymus derived lymphocytetranscription factortranscriptional silencingtranslational impacttreatment developmenttumortumorigenesisv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog
Description preview
Background. Despite the significant success of recent therapies, Acute Lymphoblastic Leukemia (ALL) remains
the second leading cause of childhood death. The discordance between therapeutic improvements and poor
outcomes is partially caused by the difficulty of salvaging relapsed disease. While outcomes have improved in
de novo treatment, dismal…
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