grant
Targeting TGFb/IFNy-IRF8 Signaling to Modulate Monocytes and their Crosstalk with Microglia and Astrocytes to Treat Multiple Sclerosis
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 30 Sept 2014Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AD modelAPOEAblationAdoptive Cell TransfersAffectAlzheimer's disease modelApo-EApoE proteinApolipoprotein EAreaAstrocytesAstrocytusAstrogliaBiscyclohexanone OxaldihydrazoneBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemBone-Derived Transforming Growth FactorCD14CD14 geneCD16CD16BCNS Nervous SystemCNS autoimmune diseaseCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemCessation of lifeClinicalClinical TrialsCritical PathsCritical PathwaysCuprizoneDataDeathDemyelinationsDiseaseDisease ProgressionDisorderDisseminated SclerosisDysfunctionEAEEnvironmentExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisFCGR3BFCGR3B geneFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFeedbackFunctional disorderGene ExpressionGenesGeneticGenetic PolymorphismGoalsHortega cellHumanIgG Fc Receptor IIIBImmune systemIn SituInfiltrationInflammatoryIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvestigationLeadLow Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BMS LesionsMS patientMacrophageMapsMarrow monocyteMediatingMicrogliaMilk Growth FactorModalityModelingModern ManMultiple SclerosisMultiple Sclerosis LesionsMφNerve DegenerationNeuraxisNeuron DegenerationPalsyParalysedPathogenicityPathologicPb elementPeripheralPhagocytesPhagocytic CellPhenotypePhysiopathologyPlatelet Transforming Growth FactorPlegiaPre-Clinical ModelPreclinical ModelsPreventionRegulationRelapseRoleSTAT1STAT1 geneSTAT91Secondary Progressive Multiple SclerosisSeveritiesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingTGF BTGF-betaTGF-βTGFbetaTGFβTimeTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransplantationadoptive cell therapyadoptive cellular therapyalzheimer modelamebocyteastrocytic gliaautoimmune encephalomyelitisbiological signal transductioncentral nervous system autoimmune diseasechronic autoimmune diseasecombinatorialdemyelinatedisabilitydisease severityeffective therapyeffective treatmentgitter cellheavy metal Pbheavy metal leadhumanized micehumanized mouseinsular sclerosisintegrin alphavbeta8integrin αvβ8interdisciplinary approachmesogliamicroglial cellmicrogliocytemonocytemouse modelmultidisciplinary approachmultiple sclerosis patientmurine modelneural degenerationneurodegenerationneurodegenerativeneurodegenerative phenotypeneurological degenerationneuronal degenerationneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionparalysisparalyticpathophysiologypatients with MSpatients with multiple sclerosispeople with Multiple sclerosisperivascular glial cellpharmacologicpolymorphismre-myelinatere-myelinationrecruitremyelinateremyelinationresponserestorationsocial roletooltransplant
Description preview
PROJECT SUMMARY
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Despite advances
in our understanding of MS pathophysiology, there are minimal disease-modifying treatments or preventions for
innate-mediated, secondary-progressive forms of MS. Our long-term goal is to define the role of interactions…
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