grant
Targeting Surfactant Protein A to Prevent Retinopathy of Prematurity
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 1 Sept 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AblationActinsAddressAngiogenesis FactorAngiogenic FactorAntibodiesAppearanceAreaAutomobile DrivingBlindnessBlood VesselsBody TissuesC-Type LectinsCell BodyCell Communication and SignalingCell FunctionCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCell divisionCellsCellular ExpansionCellular FunctionCellular GrowthCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular ProliferationChaperoneChildhoodCommon Rat StrainsComplexComplicationCytoskeletal GeneCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ProteinsCytoskeletal ReorganizationCytoskeletal SystemCytoskeletonDataDevelopmentDiseaseDisorderEndothelial CellsEvaluationEye diseasesFilopodiaGeneralized GrowthGenesGeneticGenomicsGliaGlial CellsGoalsGrowthGrowth AgentsGrowth FactorGrowth SubstancesHumanHyperoxiaImmunomodulationImpairmentIn VitroInfantInflammation MediatorsInflammatoryInjectionsInnate ImmunityInterventionIntracellular Communication and SignalingKnowledgeKolliker's reticulumLaser ElectromagneticLaser RadiationLasersLentivirinaeLentivirusLifeLigandsLung DiseasesMapsMediatingMiceMice MammalsMicroscopicModalityModelingModern ManMolecularMolecular ChaperonesMolecular TargetMuller gliaMuller's cellMurineMusMüller cellMüller gliaNative ImmunityNatural ImmunityNeural DevelopmentNeurogliaNeuroglial CellsNon-Specific ImmunityNon-neuronal cellNonneuronal cellNonspecific ImmunityO elementO2 elementOxygenPathologicPathway interactionsPhasePhenotypePhosphorylationPhysiologicPhysiologicalPlayPolymersPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPost-Translational RegulationPosttranslational ModificationsPosttranslational Protein ProcessingPosttranslational RegulationPremature BirthPremature InfantPrematurely deliveringPreterm BirthProcessPropertyProtein ModificationProtein PhosphorylationProteinsProteins Growth FactorsProteomicsPulmonary DiseasesPulmonary DisorderPulmonary Surfactant-Associated Protein AQOLQuality of lifeRNA SeqRNA sequencingRNAseqRatRats MammalsRattusReceptor CellReceptor ProteinReportingRetinaRetinal Blood VesselsRetinal DiseasesRetinal DisorderRetinal VesselsRetinopathy of PrematurityRetrolental FibroplasiaRodentRodent ModelRodentiaRodents MammalsRoleSP-A ProteinSP-A receptorShort interfering RNASightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNASocietiesStimulusSubcellular ProcessSurfactant Protein ATamoxifenTestingTherapeuticTissue GrowthTissuesTransgenic OrganismsVEGFVEGFsVascular DiseasesVascular DisorderVascular Endothelial Growth FactorsVascular ProliferationVisionVisualVisual Acuityangiogenesisbiological signal transductionblood vessel disordercell growthcell motilitycytokinedevelopmentaldisease of the lungdisorder of the lungdrivingeffective therapyeffective treatmentextracellulareye disorderhyperoxygenationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinfants born prematureinfants born prematurelyinflammatory mediatorinnovateinnovationinnovativeinterestintracellular skeletonlive cell imagelive cell imaginglive cellular imagelive cellular imaginglung disorderneovascularneovascularizationnerve cementneurodevelopmentnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetocular diseaseocular disorderontogenyophthalmopathyoverexpressoverexpressionpathwaypediatricperinatal developmentpermissivenesspolymerpolymericpolymerizationprematurepremature babypremature childbirthpremature deliverypremature infant humanpremature retinopathyprematuritypreservationpreterm babypreterm deliverypreterm infantpreterm infant humanpreventpreventingprotein foldingprotein functionpulmonaryreceptorreceptor bindingreceptor boundresponseretina blood vessel structureretina diseaseretina disorderretinal angiogenesisretinal vascular networkretinal vascular structureretinal vasculatureretinopathysiRNAside effectsocial rolespatial and temporalspatial temporalspatial temporal imagingspatial temporal mappingspatiotemporalspatiotemporal imagingspatiotemporal mappingsufractant protein A receptorsurfactant deficiencysurfactant protein A receptortargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic evaluationtherapeutic testingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstransgenicvascularvascular abnormalityvascular dysfunctionvasculopathyvision lossvisual functionvisual loss
Description preview
PROJECT SUMMARY
Retinopathy of prematurity (ROP) is a potentially blinding vaso-proliferative disease frequently seen in
prematurely born infants with lifelong consequences for both the infant and society. The c-type lectin,
Surfactant Protein A (SP-A), is an immunomodulatory protein, found to be deficient in prematurely born infants.
Lack of SP-A…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click