grant
Targeting response gene to complement 32 to alleviate vascular remodeling
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Jan 2025Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20257B4 Antigen7B4 proteinASCVDAngioplastyAnimalsAntiphosphodiesterasesArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAttenuatedBiologyBlood VesselsBody TissuesBone-Derived Transforming Growth FactorBypassCD144 AntigenCD31Cardiovascular DiseasesCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular ProliferationClinicClinicalCommon Rat StrainsComplementComplement ProteinsCore FacilityDataDevelopmentDiseaseDisorderDrug TargetingDrug TherapyDysfunctionEndothelial CellsEndotheliumEnsureEnvironmentEquipmentFailureFibrosisFunctional disorderFutureGenesGoalsGrafting ProcedureHistologicHistologicallyHumanHypertensionHypoxiaHypoxicIn VitroInfiltrationInflammatoryIntracellular Communication and SignalingKnowledgeLaboratoriesLeiomyocyteLesionLungLung Respiratory SystemMediatingMesenchymalMiceMice MammalsMilk Growth FactorMissouriModelingModern ManMolecularMurineMusN-CadherinOperative ProceduresOperative Surgical ProceduresOrgan TransplantationOrgan TransplantsOutcomeOxygen DeficiencyPECAM1PECAM1 genePPAR gammaPPAR-gPPAR-γPPARgammaPPARγPathologicPathologic ProcessesPathological ProcessesPathway interactionsPatientsPermeabilityPeroxisome Proliferative Activated Receptor GammaPeroxisome Proliferator-Activated Receptor gammaPeroxisome Proliferator-Activated Receptor γPharmacological TreatmentPharmacotherapyPhosphodiesterase AntagonistsPhosphodiesterase InhibitorsPhosphoric Diester Hydrolase InhibitorsPhysiopathologyPlatelet Transforming Growth FactorPlayPositionPositioning AttributePreventative strategyPrevention strategyPreventive strategyProcessProductionPrognosisProliferatingProteinsPublishingPulmonary HypertensionPulmonary Vascular ResistanceRatRats MammalsRattusResearchResearch ResourcesResourcesRight Ventricular HypertrophyRoleSU 5416SU5416Signal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSnailsSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSystemSystolic PressureTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeutic InterventionThiazolidinedione ReceptorTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransforming Growth FactorsTumor Growth FactorsUniversitiesUpregulationVE-CadherinVascular DiseasesVascular DisorderVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular Hypertensive DiseaseVascular Hypertensive DisorderVascular PermeabilitiesVascular remodelingVasodilating AgentVasodilator AgentsVasodilator DrugsVasodilatorsVentricularVimentinWNT Signaling PathwayWNT signalingWorkalleviate symptomameliorating symptomanimal facilityatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseattenuateattenuatesbiological signal transductionblood vessel disordercadherin 5cardiovascular disorderclinical relevanceclinically relevantcombatcomplementationcytokinedecrease symptomdevelopmentaldrug interventiondrug treatmentfewer symptomsgenetic approachgenetic strategygenome editinggenomic editinghigh blood pressurehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderhypoxia-induced pulmonary hypertensionhypoxic pulmonary hypertensionin vivoinnovateinnovationinnovativeintervention therapyintraluminal angioplastyknock-downknockdownknockout geneloss of functionlung vascular remodelingmigrationnano particle deliverynanoparticle deliverednanoparticle deliverynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetorgan allograftorgan graftorgan xenograftoverexpressoverexpressionpathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspromoterpromotorpulmonarypulmonary arterial endothelial cellpulmonary arterial hypertensionpulmonary artery endothelial cellpulmonary artery hypertensionpulmonary vascular cell proliferationpulmonary vascular remodelingreduce symptomsrelieves symptomsresponserestenosisrestorationright ventricle hypertrophyscreeningscreeningssocial rolesuccesssurgerysymptom alleviationsymptom reductionsymptom relieftooltransforming growth factors Animal growth regulatorsvascularvascular dysfunctionvasculopathy
Description preview
Summary/Abstract:
Vascular remodeling is a fundamental pathological process occurring in artery wall during the development of
numerous vascular diseases including artery restenosis following angioplasty and bypass surgery, hypertension,
organ transplantation, atherosclerosis, and pulmonary arterial hypertension (PAH). Emerging evidence indicates…
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