grant
Targeting regenerative reprogramming in colorectal cancer
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20255-FU5-Fluracil5FUATAC sequencingATAC-seqATACseqAdvisory CommitteesAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingAwardBar CodesC-K-RASCancer DrugCancer TreatmentCancersCarcinomaCell BodyCellsCellular StressCellular Stress ResponseChemotherapy and RadiationChemotherapy and/or radiationChromatinClinicalClinical TrialsColorectal CancerComputational BiologyConsensusDNA AlterationDNA Sequence AlterationDataDetectable Residual DiseaseDevelopmentDevelopment and ResearchDiagnosisDrug resistanceDrugsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial cancerEventExposure toFluoro UracilFluorouracilFluoruracilFluouracilGene TranscriptionGeneralized GrowthGeneticGenetic AlterationGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionGenotypeGoalsGrowthImmune responseInduction TherapyInflammatoryInvestigatorsK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASKnowledgeLaboratoriesLineage TracingMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of prostateMalignant prostatic tumorMedicationMedicineMentorsMentorshipMesenchymalMinimal Residual DiseaseMolecular Dynamics SimulationNEOADJNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentNeoplastic Disease Chemotherapeutic AgentsOncogene K-RasOrganoidsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPharmaceutical PreparationsPhenotypePopulationPre-Clinical ModelPreclinical ModelsProgenitor CellsProstate CAProstate CancerProstate malignancyPulmonary CancerPulmonary malignant NeoplasmR & DR&DRASK2RNA ExpressionRNA SeqRNA sequencingRNAseqRecombinant DNA TechnologyRectal NeoplasmsRectal TumorsRectum NeoplasmsRectum TumorRefractoryRefractory DiseaseResearchResearch PersonnelResearchersResidual NeoplasmResidual TumorsResistanceRiskRoleSamplingSequence AlterationTask ForcesTechnologyTestingTherapeuticTissue GrowthTranscriptionTreatment FailureTumor CellTumor EscapeTumor Immune EscapeTumor-Specific Treatment AgentsValidationadvisory teamanti-cancer druganti-cancer researchanti-cancer therapyassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbarcodecancer cellcancer evasioncancer immune escapecancer immune evasioncancer researchcancer therapycancer-directed therapycareercareer developmentcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell stresscellular lineage mappingcellular lineage trackingchemo/radiation therapychemotherapy and radiotherapyclinical translationclinically translatablecombinatorialcomputer biologycytotoxicdesigndesigningdevelopmentaldrivingdrug resistantdrug/agenteffective therapyeffective treatmentenvironmental stressesenvironmental stressorepigenetic therapyepigeneticallyepithelial carcinomaexomeexome sequencingexome-seqexosomeexperimentexperimental researchexperimental studyexperimentsexpression subtypesfitnessgenetically engineeredgenomic alterationhost responseimmune system responseimmunoresponseimproved outcomeinduction therapiesinhibitorinnovateinnovationinnovativeinnovative technologiesknock-downknockdownlung cancermalignancymetastatic colo-rectalmetastatic colo-rectal cancermetastatic colo-rectal carcinomametastatic colon cancermetastatic colorectalmetastatic colorectal cancermetastatic colorectal carcinomamolecular dynamicsmolecular sub-typesmolecular subsetsmolecular subtypesmouse modelmurine modelneoplasm/cancerneoplastic cellnon-geneticnongeneticontogenyparticipant enrollmentpatient enrollmentpatient oriented outcomespressurepreventpreventingprogramsradiation or chemotherapyregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregenerativeregenerative cellresearch and developmentresidual diseaseresistance mechanismresistance to Drugresistantresistant mechanismresistant to Drugresponseresponse biomarkerresponse markersresponse to therapyresponse to treatmentrestraintscRNA sequencingscRNA-seqshRNAshort hairpin RNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell technologysingle cell transcriptomic profilingsingle-cell RNA sequencingsmall hairpin RNAsmall molecular inhibitorsmall molecule inhibitorsocial rolestem cellstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy failuretherapy responsetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtooltranscriptome sequencingtranscriptomic sequencingtreatment responsetreatment responsivenesstreatment strategytumortumor evasiontumor immune evasionv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homologvalidations
Description preview
ABSTRACT
Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to
treatment-refractory tumors. The expanded use of sequencing tools have led to the recognition that refractory
tumors often lack a genetic mechanism of resistance, and instead co-opt a regenerative program characterized
by…
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