grant
Targeting, Quantifying, and Isolating Heterogeneous Populations of Senescent Cells from Tissues via Cell Surface and Secreted Proteomes
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbscissionAdipocytesAdipose CellAgingBMIBMI percentileBMI z-scoreBaltimoreBiological MarkersBiologyBloodBlood GlucoseBlood Reticuloendothelial SystemBlood SerumBlood SugarBlood VesselsBlood monocyteBody TissuesBody mass indexCardiacCell Culture TechniquesCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell Surface ProteinsCell secretionCell surfaceCellular SecretionCirculationClinicalClinical ResearchClinical StudyCohort StudiesCollaborationsConcurrent StudiesDataData SetExcisionExtirpationFat CellsFatsFatty acid glycerol estersFibroblastsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryHDLHDL LipoproteinsHeavy LipoproteinsHigh Density LipoproteinsHistologyHospitalsHumanIRBIRBsImmunofluorescenceImmunofluorescence ImmunologicInstitutional Review BoardsKidneyKidney Urinary SystemLDLLDL LipoproteinsLength of LifeLipocytesLongevityLongitudinal StudiesLow-Density LipoproteinsMarrow monocyteMature LipocyteMature fat cellMetabolicMethodologyMethodsMiceMice MammalsModern ManModernizationMurineMusMusculoskeletalNeurologicNeurologicalObesityOlder PopulationOutcomeParticipantPersonalized medical approachPhenotypePhysiologicPhysiologicalPopulationPopulation HeterogeneityProteinsProteomeProteomicsQuetelet indexRemovalResearchResearch ResourcesResearch SpecimenResourcesSaintsSerumSpecimenSpectrometrySurgical RemovalTechnologyTherapeuticTimeTissuesTranslationsValidationVascular Endothelial CellWorkadiposityage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationalpha-Lipoproteinsbeta-Lipoproteinsbio-markersbiologic markerbiomarkercandidate biomarkercandidate markercell culturecell culturescell sortingcell typecomputational pipelinescorpulencedevelop therapydiverse populationsdrivers of agingexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfrailtygerodriverheterogeneous populationhuman tissueimprovedin vivoindividualized approachinsightintervention developmentlong-term studylongitudinal outcome studiesmolecular biomarkermolecular markermonocytenano particlenano-sized particlenanoparticlenanosized particlenew markernovelnovel biomarkernovel markerobese individualsobese peopleobese personobese populationobese subjectsolder groupsolder individualsolder personpersonalized approachpopulation agingpopulation diversitypre-clinicalprecision approachpreclinicalpredictive signaturepulmonaryrenalresectionsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsubcutaneoussubdermaltailored approachtargeted biomarkertargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy developmenttraittranslationtreatment developmentvalidationsvascular
Description preview
In regards to the objective to identify the secretome of senescent cells, substantial methodological and research progress has been made in identifying novel SASP proteins and refining the list of SASP biomarker candidates based on human cohorts studies. Over the last two years we have developed novel and physiologically relevant SASP profiles in…
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