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Targeting microbial dysbiosis in Food Allergy to restore tolerance

Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 25 Feb 2021Deadline 31 Jan 2026 โš ๏ธ
NIHUS FederalResearch GrantFY20250-11 years old2,3,7,8-Tetrachlorodibenzo-p-dioxin ReceptorsAH ReceptorsAffectAgonistAllergic to foodAllergy to foodAnti-Bacterial AgentsAntibody ResponseAryl Hydrocarbon ReceptorAutomobile DrivingBacteriaBacterial AntibodiesBile AcidsBreast MilkBreastmilkCell BodyCell DifferentiationCell Differentiation processCellsChildChild YouthChildren (0-21)DevelopmentDiagnosisDietDietary SupplementationDioxin ReceptorsDiseaseDisease OutcomeDisorderEnvironmental FactorEnvironmental Risk FactorEpidemicEpithelial CellsExhibitsFIZZ3FailureFoodFood AllergyFood HypersensitivityFound in Inflammatory Zone 3GI commensalGI microbiomeHomolog of Drosophila TOLLHuman MilkHuman Mother's MilkIgAIgEImmuneImmune ToleranceImmune systemImmunesImmunochemical ImmunologicImmunoglobulin AImmunoglobulin EImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsImmunomodulationIndividualInfantIntermediary MetabolismInterventionIntervention StrategiesL-TryptophanLevotryptophanLicensingLifeLife StyleLifestyleLipid ALong-Term EffectsMammary Gland MilkMediatingMetabolic ProcessesMetabolismMiceMice MammalsModernizationMolecularMother's MilkMucosaMucosal TissueMucous MembraneMurineMusNuclear TranslocatorOralPathogenesisPathogenicityPathway interactionsPlayPolyaromatic Hydrocarbon ReceptorsPopulationPrevalenceProcessProductionPublic HealthRETNReactionRegulationRegulatory T-LymphocyteRoleSolidSupplementationTCDD ReceptorsTLR proteinTLR4TLR4 geneTh-2 CellTh2 CellsTherapeutic InterventionToll HomologueToll-Like Receptor Family GeneToll-like receptorsTregTryptophanType 2 Helper CellWeaningahr ligandanti-bacterialanti-bacterial antibodyaryl hydrocarbon receptor ligandbacteria in the gutbile acid metabolismbile metabolismcellular differentiationcombinatorialcommensal bacteriacommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensal bacterial speciesdevelopmentaldiet supplementationdietsdigestive tract microbiomedrivingdysbacteriosisdysbiosisdysbioticeffective therapyeffective treatmententeric commensalenteric microbiomeenvironmental riskfood allergenfood antigengastrointestinal commensalgastrointestinal microbiomegut bacteriagut commensalgut dysbiosisgut microbiomegut-associated microbiomehuman subjectimmune modulationimmune regulationimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryinsightintervention therapyintestinal biomeintestinal commensalintestinal microbiomekidsmaternal milkmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiotamicrofloramultispecies consortianoveloral tolerancepathwaypreventpreventingregulatory T-cellsresistinresponsesocial roletoll-like receptor 4youngster

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ABSTRACT
Food allergy (FA) has become a public health concern, affecting a sizeable segment of the population. Despite

the alarming increase in its prevalence, efforts to contain the FA epidemic have been stymied by the limited

understanding of disease pathogenesis, especially the role in this process of early life gut dysbiosis. In that

regard,โ€ฆ

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Targeting microbial dysbiosis in Food Allergy to restore tolerance โ€” BOSTON CHILDREN'S HOSPITAL | UNITED STATES | Feb 20 | Dev Procure