grant
Targeting host lipid metabolism to limit tissue damage in necrotizing fasciitis
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AffectAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAttenuatedAutoregulationB anthracisB. anthracisBacillus anthracisBacteriaBacterial InfectionsBacterial Skin DiseasesBacterial skin infectionsBindingBioassayBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCell BodyCell Communication and SignalingCell ProtectionCell ReprogrammingCell SignalingCell membraneCellsCessation of lifeCholesterolCholesterol HomeostasisCoriumCritical PathsCritical PathwaysCutisCytolysinsCytoplasmic MembraneCytoprotectionDataDeathDeath RateDebridementDermisDiseaseDisease ProgressionDisorderDysfunctionEatingEffectivenessElementsExotoxinsFasciaFatsFatty acid glycerol estersFood IntakeFunctional disorderGene ExpressionGeneticGoalsGrantHomeostasisHospital AdmissionHospitalizationHost DefenseHost FactorHost Factor ProteinImageImmuneImmunesInfectionInfectious Skin DiseasesInflammationInflammatoryIntegration Host FactorsIntermediary MetabolismIntracellular Communication and SignalingLaboratoriesLearningLifeLipidsLiver X ReceptorLytotoxicityMacrophageMarrow NeutrophilMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMedical emergencyMembraneMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethodologyMicrobeMiscellaneous AntibioticModelingMolecularMolecular InteractionMorbidityMφNecrosisNecroticNecrotizing fasciitisNeutrophilic GranulocyteNeutrophilic LeukocyteOperative ProceduresOperative Surgical ProceduresOutcomePathogenesisPathogenicityPathogenicity FactorsPathologyPathway interactionsPatientsPermeabilityPhagocytesPhagocytic CellPhysiological HomeostasisPhysiopathologyPlasma MembranePlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessProductivityProteinsResearch DesignResistanceRoleS. pyogenesSepsisSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle cell seqSkinSkin TissueSoft Tissue InfectionsStreptococcus Group AStreptococcus pyogenesStreptolysinsStudy TypeSurgicalSurgical InterventionsSurgical ProcedureSurvival RateTechniquesTestingTherapeuticTherapeutic UsesTissue PreservationTissuesToxic effectToxicitiesToxinTreatment CostV vulnificusV. vulnificusVibrio vulnificusVirulenceVirulence FactorsWorkadvanced analyticsamebocyteanthracisattenuateattenuatesbacteria infectionbacterial diseasebiological signal transductioncell typecellular reprogrammingcholesterol metabolismcutaneous infectioncutaneous tissuecytoprotectivecytotoxicitydesigndesigningexperimental groupfat metabolismgain of functiongroup A strepimaginginfected skinintradermal injectionlipid metabolismlipidomicsloss of functionmembrane structuremicrobialmonomermortalitymortality ratemouse modelmurine modelneutrophilnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetpathophysiologypathwaypharmacologicplasmalemmaprogramsprotective effectresistantsingle cell next generation sequencingsingle cell sequencingskin infectionsocial rolesoft tissuestudy designsurgerytranscriptomics
Description preview
ABSTRACT/SUMMARY
Necrotizing Fasciitis (NF) or “flesh-eating disease” is a rapidly progressing bacterial infection with severe
necrosis of the dermis and underlying soft tissues. Treatment of NF requires systemic antibiotics and aggressive
surgical debridement. Even with these treatments, NF has considerable morbidity and mortality. Thus, a better…
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