grant
Targeting fibrosis to change cancer outcomes
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 15 Aug 2023Deadline 16 Aug 2028
NIHUS FederalResearch GrantFY2025(TNF)-αA549ActinsAdenocarcinoma CellAffectAgingAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApoptosisApoptosis PathwayAutoimmuneAutomobile DrivingBone-Derived Transforming Growth FactorCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCDK Inhibitor ProteinCDK4ICDKI ProteinCDKN2CDKN2 GenesCDKN2ACDKN2A geneCMM2CachectinCancer DrugCancerousCancersCausalityCause of DeathCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCellular ExpansionCellular GrowthCellular injuryChronicCicatrixCollagenConnective Tissue DiseasesConnective Tissue DisorderCyclin Kinase InhibitorCyclin-Dependent Kinase InhibitorCyclin-Dependent Kinase Inhibitor 2A GeneDataDepositDepositionDiagnosisDiseaseDisorderECMEngraftmentEnzyme GeneEnzymesEpithelial CellsEtiologyExtracellular MatrixFibroblastsFibrosing AlveolitisFibrosisGeneralized GrowthGoalsGrowthGrowth AgentsGrowth FactorGrowth SubstancesHVEMHumanHypertrophyINK4INK4AImmunofluorescenceImmunofluorescence ImmunologicIn VitroInflammationIntracellular Communication and SignalingInvoluntary MuscleKnowledgeLightLinkLungLung AdenocarcinomaLung Respiratory SystemLung Tissue FibrosisMTS1MTS1 GenesMacrophage-Derived TNFMalignant Glandular CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMiceMice MammalsMilk Growth FactorModelingModern ManMolecularMonitorMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusMusculoskeletal Pain DisorderMyofibroblastNeoplasmsNeoplastic Disease Chemotherapeutic AgentsOncogenesisOrganOrganoidsOutcomePathogenesisPathogenicityPathologicPathway interactionsPatientsPhotoradiationPlatelet Transforming Growth FactorPlayProductionProgrammed Cell DeathProteins Growth FactorsPublishingPulmonary CancerPulmonary FibrosisPulmonary malignant NeoplasmRNA SeqRNA sequencingRNAseqReceptor ProteinReportingResearchRheumatic DiseasesRheumatismRheumatologic DiseasesRheumatologic DisorderRiskRisk FactorsRoleScarsSclerodermaSignal TransductionSignal Transduction SystemsSignalingSkinSmooth MuscleStaining methodStainsStromal CellsSudan Black BSystemSystemic SclerodermaSystemic SclerosisT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTP16TSG9ATechnologyTestingTimeTissue GrowthTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTrichromeTrichrome stain methodTumor ImmunityTumor Necrosis FactorTumor Necrosis Factor-alphaTumor PromotionTumor-Specific Treatment Agentsagedaged miceaged mouseairway remodelinganti-cancer druganti-tumor immunityantitumor immunitybench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebeta-D-Galactosidasebeta-D-Galactoside galactohydrolasebeta-Galactosidasebiological signal transductioncancer immunitycausationcell damagecell growthcell injurycell typecellular damagecytokinedamage to cellsdermatosclerosisdiffuse interstitial pulmonary fibrosisdisease causationdrivingelderly micefibrosis in the lunggain of functionhigh voltage electron microscopyhuman diseaseidiopathic pulmonary fibrosisin vivoinjury to cellsinnovateinnovationinnovativeinsightknock-downknockdownlac Z Proteinloss of functionlung cancerlung developmentlung fibrosismalignancymembermuscle hypertrophyneoplasianeoplasm/cancerneoplastic growthnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold miceontogenyp14ARFp16 Genesp16INK4 Genesp16INK4A Genesp16INK4apathwaypermissivenessprogressive systemic sclerosisreceptorsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsocial roletherapeutic candidatetranscriptome sequencingtranscriptomic sequencingtumortumor growthtumorigenesistumorigenicvalidation studiesβ-D-Galactosidaseβ-D-Galactoside galactohydrolaseβ-Galactosidase
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PROJECT SUMMARY
Scleroderma (SSc) patients have more than a 300% increased risk of lung cancer, or Cancerous Scleroderma
(CSc). SSc is a chronic autoimmune connective tissue disease of unknown etiology, and has the highest
morbidity of all rheumatologic diseases. Moreover, aging is a key risk factor in SSc patients for pathological
airway…
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