grant
Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 8 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAcuteAcute myocardial infarctAcute myocardial infarctionAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdultAdult HumanAllelesAllelomorphsArterial Fatty StreakArterial ObstructionArterial OcclusionArteriesArtery ObstructionAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueBlood VesselsBlood flowCXC-R4CXCL12CXCL12 geneCXCL12 proteinCXCR-4CXCR4CXCR4 geneCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac arteryCardiac infarctionCardiocyteCardiovascular DiseasesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCessation of lifeChemokine (C-X-C Motif) Ligand 12Coronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary arteryD2S201EDataDeathDevelopmentDiabetes MellitusDiseaseDisease ProgressionDisorderDyslipidemiasEncapsulatedEndothelial CellsEndotheliumFB22FLK1FamilyFibrosisFinancial HardshipFortificationGeneralized GrowthGeneticGoalsGrowthHM89HSY3RRHealthHeartHeart DiseasesHeart InjuriesHeart Muscle CellsHeart Muscle tissueHeart arteryHeart failureHeart myocyteHeterozygoteHypertensionInfarctionIntentionIntracellular Communication and SignalingIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumKDR geneKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLAP3LCR1LESTRMacrophageMediatingMedicalMiceMice MammalsMolecularMolecular TargetMorbidityMorbidity - disease rateMurineMusMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMyocardial tissueMφNPY3RNPYRNPYRLNPYY3RNeonatalNull MouseNutrientObesityPBSFPatientsPre-B Cell Growth Stimulating FactorPre-Clinical ModelPreclinical ModelsProcessProliferatingRecoveryRecurrenceRecurrentRegulationReperfusion TherapyReportingRepressionResearchResolutionRisk FactorsRoleSCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSdf1 proteinShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSmall Interfering RNASocietiesStentsStromal Cell-Derived Factor 1TLSF-ATLSF-BTPAR1TechnologyTestingTherapeuticTissue GrowthVEGFVEGF ReceptorsVEGFRVEGFR-2VEGFR2VEGFsVPF ReceptorVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor Receptor 2Vascular Endothelial Growth FactorsVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular Permeability Factor ReceptorVascularizationVisualizationWorkadapter proteinadiposityadulthoodartery occlusionatherosclerosis plaqueatherosclerotic coronary diseaseatherosclerotic lesionsatherosclerotic plaquebiological signal transductionblood pressure elevationcardiac failurecardiac functioncardiac infarctcardiac injurycardiac ischemiacardiac regenerationcardiac repaircardiomyocytecardiovascular disordercell regenerationcellular regenerationclinical significanceclinically significantcoronary angioplastycoronary arterial diseasecoronary artery angioplastycoronary attackcoronary infarctcoronary infarctioncoronary ischemiacorpulencedevelopmentaldiabeteseffective therapyeffective treatmentelevated blood pressureepsinepsin 1fightingfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressfunction of the hearthIRHhealthy lifestyleheart attackheart cellheart disorderheart functionheart infarctheart infarctionheart ischemiaheart regenerationheart repairheterozygosityhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedincrease in blood pressureincreased blood pressureinfarctinjury and repairinnovateinnovationinnovativeinsightischemia injuryischemic cardiomyopathyischemic injurymortalitymouse modelmurine modelmyocardial ischemia/hypoxiamyocardium ischemianano medicinalnano medicinenano particlenano therapynano-sized particlenanomedicinalnanomedicinenanoparticlenanosized particlenanotherapyneovascularizationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyplaques in atherosclerosispre-clinicalpreclinicalprecursor cellpreventpreventingregeneration based therapyregeneration therapyregenerativeregenerative therapeuticsregenerative therapyrepairrepairedreperfusionresolutionsrestorationrevascularizationsNuc-SeqsiRNAsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolestandard carestandard treatmentstromal cell-derived factor-1alphatherapeutic evaluationtherapeutic targettherapeutic testingtissue repairvascular
Description preview
PROJECT SUMMARY/ABSTRACT
Lack of oxygenation and nutrients that result from narrowed arteries and reduced blood flow debilitates the
normal function of the heart, leading to severe morbidity and early mortality worldwide. This devastating acute
medical episode is often seen in patients with obstructive plaques in their arteries. As a result,…
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