grant
Targeting Early Drivers of Prostate Cancer Lineage Plasticity
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 9 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AdenocarcinomaAffinityAndrogen ReceptorAnimalsApoptosisApoptosis PathwayAutopsyBasal Transcription FactorBasal transcription factor genesBiochemicalBiopsyCancer PatientCancersCastrationCell BodyCell LineageCell modelCellsCellular modelChIP SequencingChIP assayChIP-seqChIPseqClinicClinical TrialsDNAData SetDeoxyribonucleic AcidDevelopmentEarly identificationEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEventFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGliomaHDACHDAC AgentHDAC ProteinsHDAC inhibitorHistone DeacetylaseHistone Deacetylase InhibitorHistone deacetylase inhibitionHomeo BoxesHomeoboxHumanImmunofluorescenceImmunofluorescence ImmunologicIn VitroInduction of ApoptosisKnock-outKnockoutLinkMalignant AdenomaMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMiceMice MammalsModern ManMurineMusNeural Stem CellNeuroendocrine Prostate CancerNeuroglial NeoplasmNeuroglial TumorNuRDNuRD complexOat cell carcinomaOutcomePDX modelPathway interactionsPatient derived xenograftPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypeProgrammed Cell DeathProliferatingProstate CAProstate CancerProstate NeoplasmsProstate TumorProstate malignancyProstatic NeoplasiaProstatic NeoplasmsProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor InhibitionReceptor SignalingRepressionRiskRoleSafetySmall Cell Lung CancerStem Cell likeSurgical CastrationTestingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransitional CellTranslatingTumor CellUpregulationXtandianalyze gene expressionanalyzing longitudinalandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancercastration resistant CaPcastration resistant PCacastration resistant prostate cancerchromatin immunoprecipitationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcofactordemethylationdevelopmentaldrug developmentdrug standardeffective therapyeffective treatmentenzalutamideepigeneticallygain of functiongene expression analysisgene expression assayglial-derived tumorhormone refractory prostate cancerin vivoinhibitorknock-downknockdownlongitudinal analysisloss of functionlung oat cell carcinomalung small cell neuroendocrine carcinomamalignancymembernecropsyneoplasm/cancerneoplastic cellnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneuroendocrine differentiationneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitoroat cell cancerpathwaypatient derived xenograft modelpatient oriented outcomespostmortempreventpreventingprogenitor and neural stem cellsprogenitor capacityprogenitor cell likeprogenitor-likeprogramspromoterpromotorprostate cancer cellprostate cancer resistant to androgenprostate tumor cellreceptor expressionresponse biomarkerresponse markersscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall cell lung carcinomasmall cell undifferentiated carcinomasocial rolestem cell characteristicsstem-likestemnesstranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtransdifferentiationtumor
Description preview
Lineage plasticity (LP)—most commonly exemplified by loss of androgen receptor (AR) signaling and
switch from a luminal to an alternate differentiation program—is now recognized as a critical determinant of
lethality. Most efforts in the field are focused on factors that promote terminal differentiation of specific LP
subtypes such as…
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