grant
Tacrolimus-eluting nerve guidance conduit for enhanced regeneration in critical-sized peripheral nerve injuries
Organization MICROSURGICAL INNOVATIONS, INC.Location SALT LAKE CITY, UNITED STATESPosted 30 Sept 2019Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026AccidentsAddressAdvanced DevelopmentAdverse effectsAdverse reactionsAffectAllograftingAnimal ModelAnimal Models and Related StudiesAutograftAutologous TransplantationAutotransplantBenchmarkingBest Practice AnalysisBiomedical EngineeringBiomedical ResearchChronic disabilityClinicalClinical TrialsCollaborationsCommon Rat StrainsConsultationsDedicationsDevelopment and ResearchDevice DesignsDevicesDiffusionDrug ApprovalDrugsEngineeringEnsureEnvironmentFDA approvedFK 506FK506FoundationsFunctional impairmentGoalsGood Manufacturing ProcessGood manufacturing practiceGuidelinesHealth Care CostsHealth CostsHumanImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIncidenceIndividualInjuryLeadLeftLong-Term CareLytotoxicityMarketingMedical DeviceMedical RehabilitationMedicationMethodologyMethodsMicrosurgeryMissionModelingModern ManNational Institutes of HealthNatural regenerationNerveNerve RegenerationNeuro-regenerationNeurologyNeuroregenerationNeurosciencesOperative ProceduresOperative Surgical ProceduresPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPerformancePeripheral nerve injuryPersistent disabilityPharmaceutical PreparationsPharmacologyPhasePositionPositioning AttributePreparationProceduresPropertyPublic HealthQOLQuality of lifeR & DR&DRatRats MammalsRattusRecovery of FunctionRegenerationRegenerative MedicineRegulatory AffairsRegulatory PathwayRehabilitationRehabilitation therapyReoperationRepeat SurgeryResearchSafetySecureSiteSurgicalSurgical InterventionsSurgical ProcedureTacrolimusTechniquesTechnologyTestingTherapeuticToxicity TestingToxicity TestsUnited States National Institutes of Healthautologous graftautotransplantationbench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebenchmarkbio-engineeredbio-engineersbiocompatibilitybioengineeringbiological engineeringbiomaterial compatibilitycaprolactonechronic painclinical applicabilityclinical applicationcommercial scale manufacturingcommercializationconsultationcytotoxicitydesigndesigningdiffuseddiffusesdiffusingdiffusionsdisabilitydosagedrug detectiondrug developmentdrug testingdrug/agenteffective therapyeffective treatmentepsilon-caprolactoneextended carefunctional recoverygood laboratory practiceheavy metal Pbheavy metal leadimmune suppressive agentimmune suppressorimmunosuppressive substanceimmunosuppressorimprovedimproved outcomein vivoinjuriesinnovateinnovationinnovativeinnovative technologiesirritationlong-term rehabilitationmanufacturemanufacturing processmanufacturing ramp-upmanufacturing scale-upmodel of animalmultidisciplinarynerve gapnerve injurynerve reconstructionnerve repairnervous system regenerationneural injuryneural regenerationneuroprotectionneuroprotectiveneuroregenerativenew approachesnext generationnon-drugnondrugnovel approachesnovel strategiesnovel strategypathwaypatient oriented outcomesperipheral nerve crush injuriesperipheral nerve repairpreparationsprocess improvementprototyperegenerateregenerated nerveregeneration potentialregenerative potentialrehab therapyrehabilitativerehabilitative therapyresearch and developmentresearch facilitysafety assessmentscale up batchscale up productionsciatic nervestandard carestandard of carestandard treatmentsuccesssurgerysurgery outcomesurgical outcomesystemic toxicitytherapeutically effectivetranslational medicinetraumatic eventtreatment and outcomeupscale manufacturing
Description preview
PROJECT SUMMARY/ABSTRACT
This project aims to commercialize a state-of-the-art FK506-eluting, biodegradable nerve conduit designed to
improve the treatment and outcomes of peripheral nerve injuries dramatically. Peripheral nerve injuries, which
can result from a variety of causes, including accidents and surgical interventions, often lead to…
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