grant
Systems genetics of premorbid and cocaine use traits in a rat reduced complexity cross
Organization NORTHEASTERN UNIVERSITYLocation BOSTON, UNITED STATESPosted 7 Mar 2024Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY2025BehaviorBehavioralBrainBrain Nervous SystemBrain regionCNS plasticityCandidate Disease GeneCandidate GeneCell Communication and SignalingCell SignalingChromosome MappingCocaineCocaine AddictionCocaine DependenceCommon Rat StrainsComplexCrystal MethCrystal methamphetamineDNAData SetDeoxyephedrineDeoxyribonucleic AcidDesoxyephedrineDrugsEncephalonExonsFDA approvedFemaleFutureGWA studyGWASGene LocalizationGene MappingGene Mapping GeneticsGene variantGenesGeneticGenetic CrossesGenome MappingsGenotypeHeritabilityImpulsivityInbred SHR RatsInbred StrainInbreedingInduced DNA AlterationInduced MutationInduced Sequence AlterationIntakeIntracellular Communication and SignalingInvestigatorsLeadLinkage MappingLocomotor ActivityMapsMedicationMessenger RNAMethamphetamineMethylamphetamineMiceMice MammalsModelingMolecularMotor ActivityMurineMusN-MethylamphetamineNetwork AnalysisNeurobiologyNeuronal PlasticityNucleus AccumbensPathway AnalysisPb elementPharmaceutical PreparationsPhenotypePrefrontal CortexProteinsProteomicsPublic HealthQTLQuantitative Trait LociRNA SeqRNA sequencingRNAseqRatRats MammalsRattusResearch PersonnelResearchersRewardsRiskRisk FactorsRodentRodentiaRodents MammalsSHR RatsSaccharoseSalineSaline SolutionSignal TransductionSignal Transduction SystemsSignalingSpontaneously Hypertensive RatsSucroseSystemTherapeuticTotal Human and Non-Human Gene MappingTrainingTranscriptTranscriptional ControlTranscriptional RegulationTranslationsValidationVariantVariationaddicted to cocaineaddictionaddiction to cocaineaddictive disorderallelic variantbehavior phenotypebehavioral phenotypingbiological signal transductionbiomarker arraybiomarker panelbrain tissuecandidate identificationcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcentral nervous system plasticitycocaine addictedcocaine seekingcocaine self-administrationcocaine usedesigndesigningdifferential expressiondifferentially expresseddrug actiondrug/agententire genomeforward geneticsfull genomefunctional genomicsgenetic approachgenetic mappinggenetic strategygenetic variantgenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadindelinsertion/deletioninsertion/deletion mutationinsightmRNAmalemarker panelmethmultiomicsmultiple omicsmutation correctionneural plasticityneurobiologicalneuroplasticneuroplasticitynovelpanomicspsychostimulant use disorderself-administer cocainespontaneous hypertensive ratstimulant use disorderstructural mutationstructural variantstructural variationtraittranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslationtranslation to humanstranslational opportunitiestranslational potentialvalidationswhole genomewhole genome association analysiswhole genome association study♀♂
Description preview
PROJECT SUMMARY
Stimulant use disorders (e.g., cocaine, methamphetamine) are a major public health concern. Despite a
heritability of ~40-50%, genome-wide association studies (GWAS) have identified very few loci, including one hit
for cocaine (COC) dependence that maps to FAM53B, a gene also identified via expression quantitative trait
locus (QTL)…
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