grant
Systemic Mediators and Biomarkers of Injury in Preterm Infants with Intermittent Hypoxemia
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 12 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldAcquired brain injuryAdultAdult HumanAnimal ModelAnimal Models and Related StudiesApneaAxonBBB crossingBBB functionBasic ResearchBasic ScienceBiological MarkersBloodBlood - brain barrier anatomyBlood PlasmaBlood Reticuloendothelial SystemBlood-Brain BarrierBrain InjuriesCNS Nervous SystemCaffeineCaringCell BodyCell Culture SystemCell Culture TechniquesCell DeathCellsCellular injuryCentral Nervous SystemCessation of lifeClinicalClinical InvestigatorClinical MarkersClinical SciencesCommentCommentaryComplementComplement ProteinsDataDeathDevelopmentDevelopment PlansDiseaseDisorderDoctor of MedicineDoctor of PhilosophyDropsELISAEarly identificationEditorial CommentEnzyme-Linked Immunosorbent AssayEventExclusionFrequenciesFutureGenerationsGoalsHealth Care CostsHealth CostsHemato-Encephalic BarrierHypoxemiaImpairmentIn VitroIncubatedInfantInflammationInflammatoryInjuryInterventionKnowledgeLeadLearningLigandsLinkLung DiseasesM.D.MeasuresMediatorMentorsMentorshipMethodsMonitorMorbidityMorbidity - disease rateNF-LNeonatal Intensive CareNeonatal Intensive Care UnitsNervous System InjuriesNervous System TraumaNervous System damageNeuraxisNeurodevelopmental ImpairmentNeurofilament-LNeurologic outcomeNeurologic statusNeurological DamageNeurological InjuryNeurological outcomeNeurological statusNeurological traumaNewborn InfantNewborn Infant Intensive CareNewborn Intensive Care UnitsNewbornsNursesO elementO2 elementOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomeOxygenPathway interactionsPatientsPatternPb elementPh.D.PhDPlasmaPlasma SerumPremature BirthPremature InfantPrematurely deliveringPreterm BirthProbabilistic ModelsProbability ModelsProcessProgenitor CellsProtein FragmentProteomicsPublished CommentPulmonary DiseasesPulmonary DisorderQOLQuality of lifeReceptor ProteinResearchReticuloendothelial System, Serum, PlasmaRiskRoleScienceScientistSeveritiesStatistical ModelsStructureSupplementationTIL4TLR2TLR2 geneTLR2 receptorTechniquesTestingTimeTitrationsToll-Like Receptor 2Toll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4TrainingTranslational ResearchTranslational ScienceTreatment EffectivenessUrineVentilatorViewpointWorkadulthoodbio-markersbiologic markerbiomarkerbiomarker identificationblood-brain barrier crossingblood-brain barrier functionbloodbrain barrierbloodbrain barrier crossingbloodbrain barrier functionbrain cellbrain damagebrain-injuredcare costscell culturecell culturescell damagecell injurycellular damageclinical biomarkersclinically useful biomarkerscohortcompare to controlcomparison controlcomplementationdamage to cellsdevelop therapydevelopmentaldisease of the lungdisorder of the lungearly biomarkersearly detection biomarkersearly detection markersefficacious therapyefficacious treatmentenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsextreme prematurityextremely premature infantextremely pretermextremely preterm infantheavy metal Pbheavy metal leadhypoxemicidentification of biomarkersidentification of new biomarkersimprovedindexinginfants born prematureinfants born prematurelyinhibitorinjuriesinjury to cellsintervention developmentlab experiencelab traininglaboratory experiencelaboratory traininglung disorderlung functionmarker identificationmodel of animalnecrocytosisneonatal ICUneonatal breathingneonatal morbidityneonatal outcomeneonatal respirationneonatal respiratoryneurobehaviorneurotraumanewborn breathingnewborn childnewborn childrennewborn morbiditynewborn respiratorynurseoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem celloutcome predictionpathwayprematurepremature babypremature childbirthpremature deliverypremature infant humanprematuritypreterm babypreterm deliverypreterm infantpreterm infant humanprognosticationprospectivepulmonary functionreceptorrespiratoryskills trainingsocial rolesocietal costsstatistical linear mixed modelsstatistical linear modelsstem cellssynergismsystemic inflammationsystemic inflammatory responsetherapy developmenttooltranslation researchtranslational investigationtranslational investigatortranslational researchertranslational scientisttreatment developmenttreatment strategyvery prematurevery pretermwhite matter injury
Description preview
ABSTRACT
This proposal describes a mentored training and research plan that will facilitate the development of Elie
Abu Jawdeh, M.D., Ph.D., to an independent clinical and translational investigator in neonatal respiratory control
and intermittent hypoxemia (IH). Dr. Abu Jawdeh will complement his current background as a neonatologist
and a…
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