grant
Synthetic Reconstruction of Human Chaperone Networks in Yeast Models of Neurodegeneration
Organization TEMPLE UNIV OF THE COMMONWEALTHLocation PHILADELPHIA, UNITED STATESPosted 15 Mar 2023Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026110-kDa heat shock proteinAD and related dementiaAD related dementiaADRDAdvisory CommitteesAgingAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAssayBioassayBiochemistryBiological AssayBiological ChemistryBrain DiseasesBrain DisordersCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCell BodyCell modelCellsCellular AssayCellular modelChaperoneCollaborationsComplementComplement ProteinsComplexCytoplasmDNA mutationDegenerative Neurologic DisordersEncephalon DiseasesEngineeringEnzyme GeneEnzymesEukaryotaEukaryoteFTD dementiaFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrontal Temporal DementiaFrontotemporal DementiaFundingFutureGene variantGenesGeneticGenetic ChangeGenetic TechnicsGenetic TechniquesGenetic defectGenetic mutationGoalsHSP110 proteinsHeat shock proteinsHumanIn VitroIndividualIntracranial CNS DisordersIntracranial Central Nervous System DisordersLearning SkillLibrariesMT-bound tauMapsMeasuresMentorsMessenger RNAModelingModern ManMolecular ChaperonesMolecular GeneticsMutationNational Institutes of HealthNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsOrganismPathologicPennsylvaniaPhasePhenotypePopulationPositionPositioning AttributePostdocPostdoctoral FellowPreparationPreventionProcessProteinsProteomeRNA SplicingReporter GenesResearchResearch AssociateSpecificitySplicingStressSystemTAR DNA binding protein 43 kDa pathologyTAR DNA binding protein 43 pathologyTAR DNA binding protein of 43 proteinopathyTAR DNA-binding protein 43TDP-43TDP-43 aggregateTDP-43 aggregationTDP43TDP43 aggregateTDP43 aggregationTDP43 associated neurodegenerationTDP43 associated neurodegenerative diseaseTDP43 associated pathologiesTDP43 induced neurodegenerationTDP43 neurodegenerationTDP43 neurodegenerative diseaseTDP43 neuropathologyTDP43 pathogenesisTDP43 pathologyTDP43 proteinopathyTDP43 related neurodegenerationTDP43 related pathologyTask ForcesTau forming aggregatesTestingToxic effectToxicitiesTrainingTrans active response DNA binding protein 43 pathologyTrans active response DNA binding protein of 43 kDa proteinopathyTranslatingTriplet Multiple BirthTripletsUnited States National Institutes of HealthUniversitiesWorkYeast Model SystemYeastsaberrant folded proteinaberrant folded proteinsaberrant protein foldingabnormal folded proteinabnormal folded proteinsabnormal protein foldingabnormal protein homeostasisabnormal proteostasisabnormally aggregated tau proteinactivating CRISPR technologyadvisory teamage associatedage correlatedage dependentage linkedage relatedage specificaggregation in tauallelic variantcell assaycombatcombinatorialcomplementationdefective proteostasisdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesexperimentexperimental researchexperimental studyexperimentsfilamentous tau inclusionflow cytophotometryfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagenetic approachgenetic strategygenetic technologygenetic variantgenome mutationgenomic variantheat-shock proteins 110in vitro Assayinsightliving systemmRNAmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumisfolded proteinmisfolded proteinsmutantneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneuronal survivalnew approachesnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpaired helical filament of taupathologic protein foldingpost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpreparationsprogramsprotein TDP-43protein TDP43protein expressionprotein homeostasisprotein homeostasis declineprotein homeostasis deficiencyprotein homeostasis dysfunctionprotein homeostasis failureprotein homeostasis lossprotein misfoldingprotein purificationproteostasisproteostasis declineproteostasis defectproteostasis deficiencyproteostasis dysfunctionproteostasis dysregulationproteostasis failureproteostasis impairmentproteostasis lossproteotoxic proteinproteotoxinreconstructionresearch associatesscreeningscreeningsself-aggregate tauskill acquisitionskill developmentskillsstress proteintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillationtau fibrillizationtau filamenttau inclusiontau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau protein accumulationtau protein aggregationtau-tau interactiontherapeutic targettooltrans active response DNA binding protein 43 kDa pathologytrans active response DNA binding protein 43 proteinopathyyeast modelτ Proteinsτ aggregation
Description preview
Project Summary
In aging neurons, the accumulation of key misfolded proteins into aggregates is a hallmark of many
neurodegenerative diseases. For example, pathological forms of TDP43 become mislocalized to the cytoplasm
and accumulate in aggregates in frontotemporal dementia (FTD) and other Alzheimer Disease-related
Dementias (ADRD). Highly…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click